Friedman Paul M, Jih Ming H, Skover Greg R, Payonk Greg S, Kimyai-Asadi Arash, Geronemus Roy G
DermSurgery Associates, Department of Dermatology, University of Texas Medical School, Houston 77030, USA.
Arch Dermatol. 2004 Nov;140(11):1337-41. doi: 10.1001/archderm.140.11.1337.
To quantitatively assess improvement in acne scarring after a series of nonablative laser treatments and to determine efficacy at 1-, 3-, and 6-month follow-up after treatment.
Before-after trial of consecutively selected patients.
Private practice at the Laser and Skin Surgery Center of New York, New York.
Eleven patients with mild to moderate atrophic acne scarring were treated.
A 3-dimensional optical profiling imaging system was used to assess skin topography before, during, and after treatment. Patients were treated with a 1064-nm Q-switched Nd:YAG laser and reassessed after 3 treatment sessions and at 1, 3, and 6 months after the fifth treatment session.
The skin roughness analysis was quantified at baseline and at each follow-up interval. Pain, erythema, and petechiae formation were assessed on 3-point scales.
At midtreatment (1 month after the third treatment session), an 8.9% improvement in roughness analysis was seen. This improvement increased to 23.3%, 31.6%, and 39.2% at 1, 3, and 6 months after the fifth treatment, respectively. Patients reported mild to moderate pain with treatment. The only adverse effects noted were transient erythema and mild pinpoint petechiae.
Treatment with the nonablative 1064-nm Q-switched Nd:YAG laser results in significant quantitative improvements in skin topography in patients with mild to moderate atrophic acne scars. Continued incremental improvements were noted at 1-, 3-, and 6-month follow-up, indicating ongoing dermal collagen remodeling after the treatment.
定量评估一系列非剥脱性激光治疗后痤疮瘢痕的改善情况,并确定治疗后1个月、3个月和6个月随访时的疗效。
对连续入选患者进行前后对照试验。
纽约激光与皮肤外科中心私人诊所。
11例轻度至中度萎缩性痤疮瘢痕患者接受治疗。
使用三维光学轮廓成像系统在治疗前、治疗期间和治疗后评估皮肤表面形态。患者接受1064nm调Q Nd:YAG激光治疗,在3次治疗后以及第5次治疗后1个月、3个月和6个月进行重新评估。
在基线和每个随访间隔对皮肤粗糙度进行量化分析。采用3分制评估疼痛、红斑和瘀点形成情况。
治疗中期(第3次治疗后1个月),粗糙度分析改善了8.9%。在第5次治疗后1个月、3个月和6个月,这种改善分别增至23.3%、31.6%和39.2%。患者报告治疗时伴有轻至中度疼痛。观察到的唯一不良反应为短暂性红斑和轻度针尖样瘀点。
非剥脱性1064nm调Q Nd:YAG激光治疗可使轻度至中度萎缩性痤疮瘢痕患者的皮肤表面形态在数量上得到显著改善。在1个月、3个月和6个月随访时均观察到持续的渐进性改善,表明治疗后真皮胶原持续重塑。