Uyeki Timothy M, Chong Yu-Hoi, Katz Jacqueline M, Lim Wilina, Ho Yuk-Yin, Wang Sophia S, Tsang Thomas H F, Au Winnie Wan-Yee, Chan Shuk-Chi, Rowe Thomas, Hu-Primmer Jean, Bell Jensa C, Thompson William W, Bridges Carolyn Buxton, Cox Nancy J, Mak Kwok-Hang, Fukuda Keiji
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2002 Feb;8(2):154-9. doi: 10.3201/eid0802.010148.
In April 1999, isolation of avian influenza A (H9N2) viruses from humans was confirmed for the first time. H9N2 viruses were isolated from nasopharyngeal aspirate specimens collected from two children who were hospitalized with uncomplicated, febrile, upper respiratory tract illnesses in Hong Kong during March 1999. Novel influenza viruses have the potential to initiate global pandemics if they are sufficiently transmissible among humans. We conducted four retrospective cohort studies of persons exposed to these two H9N2 patients to assess whether human-to-human transmission of avian H9N2 viruses had occurred. No serologic evidence of H9N2 infection was found in family members or health-care workers who had close contact with the H9N2-infected children, suggesting that these H9N2 viruses were not easily transmitted from person to person.
1999年4月,首次证实从人类身上分离出甲型禽流感(H9N2)病毒。从1999年3月在香港因单纯性发热性上呼吸道疾病住院的两名儿童所采集的鼻咽抽吸物标本中分离出了H9N2病毒。新型流感病毒如果在人类中具有足够的传播能力,就有可能引发全球大流行。我们对接触这两名H9N2患者的人员进行了四项回顾性队列研究,以评估甲型H9N2禽流感病毒是否发生了人际传播。在与感染H9N2的儿童有密切接触的家庭成员或医护人员中,未发现H9N2感染的血清学证据,这表明这些H9N2病毒不易在人与人之间传播。