Colbert Lisa H, Hartman Terryl J, Tangrea Joseph A, Pietinen Pirjo, Virtamo Jarmo, Taylor Philip R, Albanes Demetrius
Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Int J Cancer. 2002 Apr 10;98(5):770-3. doi: 10.1002/ijc.10156.
We examined the association between physical activity and lung cancer in a prospective cohort of 27,087 male smokers, ages 50-69 years, enrolled in the Alpha-Tocopherol, Beta Carotene Cancer Prevention (ATBC) Study. After an average of 10 years of follow-up, 1,442 lung cancer cases were diagnosed. Cox proportional hazards models were used to estimate the relative risk (RR) and 95% confidence intervals (CI) of lung cancer associated with self-reported occupational and leisure-time activity, adjusted for age, supplement group, body mass index, cigarettes smoked daily, years of smoking, education, energy intake and vegetable intake. There were no associations between occupational, leisure-time or combined categories of physical activity with lung cancer risk; however, age appeared to modify the effect of leisure-time activity (p = 0.02). Within increasing quartiles of age, the RRs (CI) for men active in leisure time compared to sedentary men were 0.77 (0.54-1.09), 0.74 (0.57-0.95), 1.09 (0.89-1.33) and 1.03 (0.88-1.21). These data suggest that among smokers, neither occupational nor leisure-time activity is associated with lung cancer risk. There may, however, be some modest risk reduction associated with leisure activity among younger smokers. Published 2002 Wiley-Liss, Inc.
我们在一项针对27,087名年龄在50至69岁之间的男性吸烟者的前瞻性队列研究中，考察了身体活动与肺癌之间的关联。该研究纳入了α-生育酚、β-胡萝卜素癌症预防（ATBC）研究。经过平均10年的随访，共诊断出1,442例肺癌病例。采用Cox比例风险模型来估计与自我报告的职业和休闲活动相关的肺癌相对风险（RR）及95%置信区间（CI），并对年龄、补充剂组、体重指数、每日吸烟量、吸烟年限、教育程度、能量摄入和蔬菜摄入量进行了校正。职业活动、休闲活动或综合身体活动类别与肺癌风险之间均无关联；然而，年龄似乎会改变休闲活动的影响（p = 0.02）。在年龄递增的四分位数范围内，与久坐男性相比，休闲时间活跃男性的RR（CI）分别为0.77（0.54 - 1.09）、0.74（0.57 - 0.95）、1.09（0.89 - 1.33）和1.03（0.88 - 1.21）。这些数据表明，在吸烟者中，职业活动和休闲活动均与肺癌风险无关。然而，在年轻吸烟者中，休闲活动可能会有一定程度的风险降低。2002年由Wiley - Liss, Inc.出版。
