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非人类哺乳动物乳汁和初乳中的寡糖。

Oligosaccharides of milk and colostrum in non-human mammals.

作者信息

Urashima T, Saito T, Nakamura T, Messer M

机构信息

Department of Bio Resource Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Hokkaido, 080-8555, Japan.

出版信息

Glycoconj J. 2001 May;18(5):357-71. doi: 10.1023/a:1014881913541.

DOI:10.1023/a:1014881913541
PMID:11925504
Abstract

Mammalian milk or colostrum usually contains, in addition to lactose, a variety of neutral and acidic oligosaccharides. Although the oligosaccharides of human milk have been reviewed in several recent publications, those of non-human mammals have received much less attention. This paper reviews the chemical structures and the variety of milk oligosaccharides in species other than humans, including placental mammals (e.g. primates, domestic herbivores, bears and other carnivores, the rat and the elephant) as well as monotremes (platypus and echidna) and marsupials (e.g. wallaby). The gastrointestinal digestion and absorption and the possible biological functions of these oligosaccharides are also discussed.

摘要

除乳糖外,哺乳动物的乳汁或初乳通常还含有多种中性和酸性低聚糖。尽管近期已有多篇出版物对人乳中的低聚糖进行了综述,但非人类哺乳动物的低聚糖受到的关注要少得多。本文综述了除人类以外其他物种乳汁中低聚糖的化学结构和种类,包括胎盘哺乳动物(如灵长类动物、家养食草动物、熊和其他食肉动物、大鼠和大象)以及单孔目动物(鸭嘴兽和针鼹)和有袋动物(如沙袋鼠)。还讨论了这些低聚糖在胃肠道中的消化吸收及其可能的生物学功能。

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Creation of a milk oligosaccharide database, MilkOligoDB, reveals common structural motifs and extensive diversity across mammals.创建了一个牛奶低聚糖数据库 MilkOligoDB,揭示了哺乳动物中常见的结构基序和广泛的多样性。
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Investigations of the in vitro transport of human milk oligosaccharides by a Caco-2 monolayer using a novel high performance liquid chromatography-mass spectrometry technique.使用新型高效液相色谱-质谱技术,通过Caco-2单层细胞对人乳寡糖的体外转运进行研究。
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