Baran Cihat Nazmi, Celebioğlu Selim, Sensöz Omer, Ulusoy Gürhan, Civelek Birol, Ortak Turgut
Department of Plastic and Reconstructive Surgery, Ankara Numune Research and Training Hospital, Ankara, Turkey.
Plast Reconstr Surg. 2002 Apr 15;109(5):1646-51; 1652. doi: 10.1097/00006534-200204150-00023.
Fat grafts are used for soft-tissue augmentation of various anatomic regions, most frequently for the improvement of facial contours. Resorption of the graft is the main problem, and several different procedures have been described to minimize this phenomenon. Using 25 New Zealand rabbits, the behavior of fat grafts in a highly vascularized recipient site was studied. The recipient sites prepared on the backs of the rabbits were divided into four regions. A capsule formation with silicone sheet application was accomplished in two of these recipient areas before the transplantation of the fat grafts. Fat grafts were placed in the other two recipient areas without any prior preparation. We prepared two types of fat tissue; in one the lobular structure was preserved and in the other it was manually crushed and rinsed with lactated Ringer's solution. The fat tissues with preserved lobular structure were placed in area I and area III. Manually crushed and rinsed fat tissues were placed in area II and area IV. In areas III and IV, a capsule formation with silicone sheet had been accomplished 3 weeks before grafting. Biopsy samples were obtained from these sites at the end of the first, third, sixth, and tenth months. Our aim was to observe the histologic fate of fat tissue in different recipient areas. The macroscopic and microscopic evaluation of the fat grafts in areas with silicone sheet indicated significant differences in the resorption time of the fat grafts; however, it was concluded that the significant resorption of the transplanted autologous fat tissue grafts at the end of the first year was an inevitable consequence of fat grafting.
脂肪移植用于多种解剖区域的软组织填充，最常用于改善面部轮廓。移植脂肪的吸收是主要问题，已经描述了几种不同的方法来尽量减少这种现象。使用25只新西兰白兔，研究了脂肪移植在高度血管化受体部位的行为。在兔背部制备的受体部位分为四个区域。在脂肪移植前，其中两个受体区域通过应用硅胶片形成了包膜。另外两个受体区域未做任何预处理就植入了脂肪移植体。我们制备了两种类型的脂肪组织；一种保留了小叶结构，另一种经手工挤压并用乳酸林格氏液冲洗。保留小叶结构的脂肪组织被放置在区域I和区域III。手工挤压并冲洗过的脂肪组织被放置在区域II和区域IV。在区域III和IV，移植前3周通过硅胶片形成了包膜。在第1、3、6和10个月末从这些部位获取活检样本。我们的目的是观察不同受体区域脂肪组织的组织学转归。对有硅胶片区域的脂肪移植体进行的宏观和微观评估表明，脂肪移植体的吸收时间存在显著差异；然而，得出的结论是，移植的自体脂肪组织移植体在第一年末的显著吸收是脂肪移植不可避免的结果。
