Devine Deirdre A, Hancock Robert E W
Division of Oral Biology, Leeds Dental Institute, University of Leeds, Leeds, England LS2 9LU.
Curr Pharm Des. 2002;8(9):703-14. doi: 10.2174/1381612023395501.
Cationic antimicrobial peptides are observed throughout nature. In mammals they are observed both at epithelial surfaces and within the granules of phagocytic cells. They are an important component of innate defences, since in addition to their ability to kill microorganisms, they are able to modulate inflammatory responses. With respect to their ability to kill bacteria, it is very difficult to isolate resistant mutants. However there are a few known mechanisms of intrinsic resistance, including PhoPQ-dependent and other alterations in lipopolysaccharide structure that influence self promoted uptake, and protease-mediated resistance.
阳离子抗菌肽在自然界中广泛存在。在哺乳动物中，它们存在于上皮表面和吞噬细胞的颗粒内。它们是先天防御的重要组成部分，因为除了具有杀灭微生物的能力外，还能够调节炎症反应。就其杀灭细菌的能力而言，很难分离出耐药突变体。然而，已知有一些内在耐药机制，包括 PhoPQ 依赖性以及脂多糖结构的其他改变，这些改变会影响自身促进摄取，还有蛋白酶介导的耐药性。
