Noshchenko Andriy G, Zamostyan Pavlo V, Bondar Oleksandra Yu, Drozdova Vira D
Department of Environmental Sciences, National University Kiev-Mohyla Academy, Kiev, Ukraine.
Int J Cancer. 2002 Jun 1;99(4):609-18. doi: 10.1002/ijc.10406.
A case-control study was conducted to estimate the radiation-induced acute leukemia risk for the period 1987-1997 among residents aged 0-20 at the time of the Chernobyl accident in the most radioactively contaminated territories of the Ukraine (Rivno and Zhytomir regions). Data were collected on 272 leukemia cases diagnosed between 1 January 1987 and 31 December 1997. Of these, 98 cases were verified and interviewed. Verified cases were compared to 151 randomly selected controls matched by age, gender and type of settlement. The mean value of the estimated accumulated equivalent dose to the bone marrow was 4.5 mSv, and the maximum value was 101 mSv. A statistically significant increased risk of leukemia was found among males whose estimated radiation exposure was higher than 10 mSv. This association was statistically significant for acute leukemia cases that occurred in the period 1993-1997, particularly for acute lymphoblastic leukemia. A similar association was found for acute myeloid leukemia, diagnosed in the period 1987-1992.
开展了一项病例对照研究，以估算1987年至1997年期间，在乌克兰放射性污染最严重地区（罗夫诺和日托米尔地区）切尔诺贝利事故发生时年龄在0至20岁的居民中，辐射诱发急性白血病的风险。收集了1987年1月1日至1997年12月31日期间确诊的272例白血病病例的数据。其中，98例病例得到核实并接受了访谈。将经核实的病例与151名按年龄、性别和居住类型随机选取的对照进行比较。估算的骨髓累积当量剂量平均值为4.5毫希沃特，最大值为101毫希沃特。在估算辐射暴露高于10毫希沃特的男性中，发现白血病风险有统计学意义的增加。这种关联在1993年至1997年期间发生的急性白血病病例中具有统计学意义，尤其是急性淋巴细胞白血病。在1987年至1992年期间诊断出的急性髓细胞白血病中也发现了类似关联。
