磷脂与促融脂质混合单分子层的研究。
Studies on mixed monolayers of phospholipids and fusogenic lipids.
作者信息
Maggio B, Lucy J A
出版信息
Biochem J. 1975 Sep;149(3):597-608. doi: 10.1042/bj1490597.
Abstract
- The behaviour of mixed monolayers of 14 different lipids with preparations of erythrocyte lipids, purified natural and synthetic phospholipids, cholesterol and galactosylceramide was investigated. 2. The mean areas occupied per molecule in mixed films containing lipids that are fusogenic for hen erythrocytes were compared with those for corresponding films containing lipids that are inactive as fusogens. 3. Fusogenic lipids were found to exhibit interactions, which were not shown by non-fusogenic lipids, in mixed monolayers with several species of phospholipid, particularly those containing a choline head group. 4. Heterogeneity in the hydrophobic chains of phosphatidylcholine, their degree of unsaturation and the presence of cholesterol had little effect on the interaction of phosphatidylcholine with fusogenic lipids. 5. Fusogenic lipids showed little specific interaction with natural or synthetic preparations of phosphatidylethanolamine. 6. The possible significance of these observations in relation to the action of fusogenic lipids on biological membranes is discussed in the light of the asymmetrical distribution of phospholipids in erythrocyte membranes.
摘要
- 研究了14种不同脂质与红细胞脂质制剂、纯化的天然和合成磷脂、胆固醇及半乳糖神经酰胺的混合单层的行为。2. 将含有对鸡红细胞有融合活性的脂质的混合膜中每个分子占据的平均面积，与含有无融合活性脂质的相应膜的平均面积进行了比较。3. 发现融合活性脂质在与几种磷脂的混合单层中表现出非融合活性脂质未表现出的相互作用，特别是那些含有胆碱头部基团的磷脂。4. 磷脂酰胆碱疏水链的异质性、其不饱和度以及胆固醇的存在对磷脂酰胆碱与融合活性脂质的相互作用影响很小。5. 融合活性脂质与天然或合成的磷脂酰乙醇胺制剂几乎没有特异性相互作用。6. 根据红细胞膜中磷脂的不对称分布，讨论了这些观察结果与融合活性脂质对生物膜作用的可能意义。
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