Almyroudi Alexandra, Mackenzie D, McHugh Siobhan, Saunders W P
University of Glasgow Dental School, Scotland.
J Endod. 2002 Mar;28(3):163-7. doi: 10.1097/00004770-200203000-00005.
The purpose of this study was to compare in vitro the suitability of four disinfectants as intracanal medications: calcium hydroxide, chlorhexidine gel, chlorhexidine in the form of a controlled-release delivery system (PerioChip), and the combination of chlorhexidine gel with calcium hydroxide. Saline was used as the control. The disinfectants were tested at three different time periods (3, 8, and 14 days) by using human tooth specimens that had been previously contaminated with Enterococcus faecalis. Calcium hydroxide worked very efficiently in killing E. faecalis in the 3-day group and 8-day group. It was not as effective in the 14-day group. The different chlorhexidine formulations were also found to be effective for all time periods. More specifically, the combination of chlorhexidine gel with calcium hydroxide and the chlorhexidine gel worked slightly better than the PerioChip, but there was no significant difference among the medications.
氢氧化钙、氯己定凝胶、控释给药系统形式的氯己定（派丽奥）以及氯己定凝胶与氢氧化钙的组合。使用生理盐水作为对照。通过使用先前已被粪肠球菌污染的人牙标本，在三个不同时间段（3天、8天和14天）对消毒剂进行测试。氢氧化钙在3天组和8天组中杀灭粪肠球菌的效果非常显著。在14天组中效果则没那么好。不同的氯己定制剂在所有时间段也都被发现有效。更具体地说，氯己定凝胶与氢氧化钙的组合以及氯己定凝胶的效果略优于派丽奥，但各药物之间无显著差异。
