Sel'kov E E
Eur J Biochem. 1975 Nov 1;59(1):151-7. doi: 10.1111/j.1432-1033.1975.tb02436.x.
A simple kinetic model of cell energy metabolism with autocatalytic reaction sequences has beepn analysed. The model accounts for the fact that part of energy produced in the form of ATP, or any other equivalent form, is utilized in "sparking" reactions to activate initial substrates. Analysis of the model shows that energy metabolism, in the absen-e of all non-stoichiometric (i.e. isosteric, cooperative, and allosteric) regulations, is capable of (a) stabilizing, to a high degree of accuracy, the relative concentration of the "charged form" of the energy-transferring cofactor (ATP); (b) alternating between two stable stationary states by means of hysteretic transitions; (c) generating self-oscillations in energy production. It is proposed that energy metabolism can be a source of very slow, in particular circadian (of about a one-day period), oscillations which may serve as the basis for temporal organization of the cell.
对一个具有自催化反应序列的细胞能量代谢简单动力学模型进行了分析。该模型解释了这样一个事实，即部分以ATP或任何其他等效形式产生的能量被用于“引发”反应以激活初始底物。对该模型的分析表明，在所有非化学计量（即等构、协同和别构）调节缺失的情况下，能量代谢能够：（a）高度精确地稳定能量转移辅助因子（ATP）“带电形式”的相对浓度；（b）通过滞后转变在两个稳定稳态之间交替；（c）在能量产生中产生自振荡。有人提出，能量代谢可能是非常缓慢的振荡的来源，特别是昼夜节律（约一天周期）的振荡，这可能是细胞时间组织的基础。
