Karayiannakis A J, Syrigos K N, Savva A, Polychronidis A, Karatzas G, Simopoulos C
Second Department of Surgery, Democritus University of Thrace, Medical School, 6 I. Kaviri Street, 68 100 Alexandroupolis, Greece.
Surg Endosc. 2002 Nov;16(11):1551-4. doi: 10.1007/s00464-001-9221-4. Epub 2002 Jun 20.
Elevated serum levels of the cell adhesion molecule E-cadherin have been associated with the presence of tissue injury and inflammation. We compared soluble E-cadherin response during laparoscopic and open cholecystectomy.
The E-cadherin response to surgery was studied in 16 patients undergoing laparoscopic cholecystectomy and 12 patients undergoing open cholecystectomy. Serum E-cadherin levels were measured by an enzyme immunoassay (ELISA) preoperatively, 10 and 30 min after the commencement of surgery, and at 6 and 24 h following the operation.
Serum E-cadherin levels decreased progressively during laparoscopic cholecystectomy; their concentrations at 24 h after surgery were significantly lower when compared with preoperative values. In the open cholecystectomy group, serum E-cadherin levels did not differ from preoperative values at any time point. Serum E-cadherin concentrations at 24 h after surgery and the cumulative E-cadherin response were significantly higher in the open cholecystectomy group than in the laparoscopic group.
Compared with open cholecystectomy, the cumulative E-cadherin response is significantly reduced following laparoscopic cholecystectomy.
血清中细胞黏附分子E-钙黏蛋白水平升高与组织损伤和炎症的存在有关。我们比较了腹腔镜胆囊切除术和开腹胆囊切除术期间可溶性E-钙黏蛋白的反应。
对16例行腹腔镜胆囊切除术的患者和12例行开腹胆囊切除术的患者进行了手术中E-钙黏蛋白反应的研究。术前、手术开始后10分钟和30分钟以及术后6小时和24小时通过酶免疫测定法（ELISA）测量血清E-钙黏蛋白水平。
腹腔镜胆囊切除术期间血清E-钙黏蛋白水平逐渐下降；与术前值相比，术后24小时其浓度显著降低。在开腹胆囊切除术组中，血清E-钙黏蛋白水平在任何时间点均与术前值无差异。开腹胆囊切除术组术后24小时血清E-钙黏蛋白浓度和E-钙黏蛋白累积反应显著高于腹腔镜组。
与开腹胆囊切除术相比，腹腔镜胆囊切除术后E-钙黏蛋白累积反应显著降低。
