Puthaviriyakorn Vichet, Siriviriyasomboon Narinee, Phorachata Juthamard, Pan-ox Wiphada, Sasaki Tetsuro, Tanaka Ken
Office of the Narcotics Control Board, Scientific Narcotics Detection Division, 5 Din-Deang, Bangkok 10400, Thailand.
Forensic Sci Int. 2002 Apr 18;126(2):105-13. doi: 10.1016/s0379-0738(02)00018-x.
Impurity profiles of methamphetamine tablets seized in Thailand have been investigated. The samples are extracted with small amounts of ethyl acetate under alkaline condition and the extracts are analyzed by capillary gas chromatography. Nine compounds (1,2-dimethyl-3-phenylaziridine, ephedrine, methylephedrine, N-formylmethamphetamine, N-acetylmethamphetamine, N-formylephedrine, N-acetylephedrine, N,O-diacetylephedrie, methamphetamine dimer) are identified as impurities in methamphetamine tablet. Caffeine and ethyl vanillin are also detected as diluents and/or adulterants, and acetylcodeine monoacetylmorphine and diacetylmorphine are contained in many samples. In addition, trans-3,4-dimethyl-5-phenyl-2-oxazolidone is newly found as an impurity. For characterization and comparison of methamphetamine tablet exhibits, intensely and commonly detectable nine peaks are selected as the factor for multivariate analysis. The procedures reported here permit classification of 250 analyzed exhibits into five groups and characterization of classified groups.
对在泰国查获的甲基苯丙胺片剂的杂质概况进行了调查。样品在碱性条件下用少量乙酸乙酯萃取，萃取物用毛细管气相色谱法分析。九种化合物（1,2 - 二甲基 - 3 - 苯基氮杂环丙烷、麻黄碱、甲基麻黄碱、N - 甲酰基甲基苯丙胺、N - 乙酰基甲基苯丙胺、N - 甲酰基麻黄碱、N - 乙酰基麻黄碱、N,O - 二乙酰基麻黄碱、甲基苯丙胺二聚体）被鉴定为甲基苯丙胺片剂中的杂质。咖啡因和乙基香兰素也被检测为稀释剂和/或掺杂物，许多样品中含有乙酰可待因、单乙酰吗啡和二乙酰吗啡。此外，反式 - 3,4 - 二甲基 - 5 - 苯基 - 2 - 恶唑烷酮被新发现为一种杂质。为了表征和比较甲基苯丙胺片剂的表现，选择强烈且普遍可检测的九个峰作为多变量分析的因素。本文报道的程序可将250个分析样品分为五组，并对分类组进行表征。
