Outerbridge Catherine A, Marks Stanley L, Rogers Quinton R
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Vet Dermatol. 2002 Aug;13(4):177-86. doi: 10.1046/j.1365-3164.2002.00295.x.
Plasma amino acid concentrations were measured in 36 dogs diagnosed with superficial necrolytic dermatitis (SND) via skin biopsy. The median age of the dogs was 10 years, and 27 out of 36 (75%) were male. Twenty-two out of 36 (61%) of the dogs were accounted for by six breeds; West Highland white terriers (six), Shetland sheepdogs (five), cocker spaniels (four), Scottish terriers (three), Lhasa apsos (two) and Border collies (two). The mean concentration (+/- standard deviation) was calculated for each measured plasma amino acid and compared to previously documented concentrations of plasma amino acids measured in dogs with acute and chronic hepatitis. The ratio of branched chain amino acids to aromatic amino acids in the dogs with SND was 2.6, slightly lower than that in normal dogs. The mean plasma amino acid concentrations for dogs with SND were significantly lower than for dogs with acute and chronic hepatitis. A metabolic hepatopathy in which there is increased hepatic catabolism of amino acids is hypothesized to explain the hypoaminoacidaemia seen in SND.
通过皮肤活检对36只被诊断为浅表性坏死性皮炎（SND）的犬进行血浆氨基酸浓度测定。这些犬的中位年龄为10岁，36只中有27只（75%）为雄性。36只犬中有22只（61%）属于六个品种；西部高地白梗（6只）、设得兰牧羊犬（5只）、可卡犬（4只）、苏格兰梗（3只）、拉萨犬（2只）和边境牧羊犬（2只）。计算每种测得的血浆氨基酸的平均浓度（±标准差），并与先前记录的急性和慢性肝炎犬的血浆氨基酸浓度进行比较。SND犬的支链氨基酸与芳香族氨基酸的比例为2.6，略低于正常犬。SND犬的平均血浆氨基酸浓度显著低于急性和慢性肝炎犬。推测存在一种氨基酸肝脏分解代谢增加的代谢性肝病，以解释SND中所见的低氨基酸血症。
