Trnavský K, Zachar M
Agents Actions. 1975 Dec;5(5):549-52. doi: 10.1007/BF01972693.
An inverse correlation was found between the serum aspirin esterase activity in human subjects and the biological half-life of salicylic acid in serum and a direct relationship between the values of the elimination rate constant and the activity of this enzyme. The rate of acetylsalicylic acid breakdown may be one of the factors which influences the biological half-life of salicylates in the organism and may participate also in determining the individual response to the administered drug.
在人体受试者中，血清阿司匹林酯酶活性与血清中水杨酸的生物半衰期之间呈负相关，而消除速率常数的值与该酶的活性之间呈正相关。乙酰水杨酸的分解速率可能是影响机体中水杨酸盐生物半衰期的因素之一，也可能参与决定个体对所给药的反应。
