狼疮性肾炎患者DNA结合能力模式的预后意义
Prognostic significance of DNA-binding capacity patterns in patients with lupus nephritis.
作者信息
Adler M K, Baumgarten A, Hecht B, Siegel N J
出版信息
Ann Rheum Dis. 1975 Oct;34(5):444-50. doi: 10.1136/ard.34.5.444.
Abstract
The time course of DNA binding capacity (DNA-bc) was found to correlate with the clinical course in a group of 21 patients who had biopsy-proven lupus glomerulonephritis and were treated with immunosuppressive agents. Eight patients showed a sequential DNA-bc pattern in which a high titre of anti-DNA antibody was present for a prolonged period of time all having an unfavourable clinical course. Persistently high values of DNA-bc preceded by as much as 10 months evidence of renal deterioration obtained by conventional renal function tests. Thirteen patients showed a low titre of anti-DNA antibody throughout most of their course, 12 having a favourable outcome. An initially high value of DNA-bc had no prognostic significance. These results suggest that the persistence of a high titre of anti-DNA antibody in patients with lupus glomerulonephritis is a poor prognostic sign.
摘要
在一组21例经活检证实为狼疮性肾小球肾炎并接受免疫抑制剂治疗的患者中，发现DNA结合能力（DNA-bc）的时间进程与临床进程相关。8例患者呈现出连续的DNA-bc模式，其中高滴度抗DNA抗体长时间存在，所有这些患者临床进程均不佳。DNA-bc持续高值比通过传统肾功能测试获得的肾脏恶化证据早多达10个月。13例患者在病程的大部分时间里抗DNA抗体滴度较低，其中12例预后良好。DNA-bc最初的高值无预后意义。这些结果表明，狼疮性肾小球肾炎患者中高滴度抗DNA抗体的持续存在是不良预后的标志。
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