Millar Jonathan B A
Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK, E-mail:
Genome Biol. 2002 Sep 20;3(10):REVIEWS1028. doi: 10.1186/gb-2002-3-10-reviews1028.
Using a complete set of budding-yeast mutants bearing deletions of all known open reading frames, a recent study has revealed multiple overlapping pathways that coordinately regulate cell-cycle progression with ribosome biogenesis and translation efficiency, providing new insights into the mechanisms governing cell-size homeostasis in eukaryotes..
最近一项研究利用一套完整的携带所有已知开放阅读框缺失的芽殖酵母突变体,揭示了多个重叠的途径,这些途径协调核糖体生物合成和翻译效率来调控细胞周期进程,为真核生物中控制细胞大小稳态的机制提供了新见解。