2,3,7,8-四氯二苯并-1,4-二噁英对实验室工作人员的毒性作用。
Toxic effects of 2,3,7,8 tetrachlorodibenzo 1,4 dioxin in laboratory workers.
作者信息
Oliver R M
出版信息
Br J Ind Med. 1975 Feb;32(1):49-53. doi: 10.1136/oem.32.1.49.
Abstract
The toxic effects on three young scientists who had transient minimal exposure to 2,3,7,8 tetrachlorodibenzo 1,4 dioxin (dioxin) are described. Two of them suffered from typical chloracne. Delayed symptoms about two years after initial exposure occurred in two of the scientists. These symptoms included personality changes, other neurological disturbances, and hirsutism. All three scientists were found to have raised serum cholesterol but no other biochemical disturbances, and no porphyrinuria nor liver damage was demonstrated. The question whether the unusually delayed physiological effects were in fact due to the initial dioxin exposure is discussed. Although conclusive evidence is lacking, it seems likely that these delayed effects were in fact due to dioxin intoxication.
摘要
描述了三名年轻科学家短暂少量接触2,3,7,8-四氯二苯并-1,4-二恶英（二恶英）后的毒性作用。其中两人患有典型的氯痤疮。两名科学家在初次接触约两年后出现延迟症状。这些症状包括性格改变、其他神经功能障碍和多毛症。发现所有三名科学家的血清胆固醇均升高，但无其他生化紊乱，未出现卟啉尿症，也未发现肝脏损伤。文中讨论了这些异常延迟的生理效应是否实际上是由最初的二恶英接触所致的问题。尽管缺乏确凿证据，但这些延迟效应似乎实际上是由二恶英中毒引起的。
相似文献
1
Toxic effects of 2,3,7,8 tetrachlorodibenzo 1,4 dioxin in laboratory workers.2,3,7,8-四氯二苯并-1,4-二噁英对实验室工作人员的毒性作用。
Br J Ind Med. 1975 Feb;32(1):49-53. doi: 10.1136/oem.32.1.49.
2
Dioxin, chloracne, and soft tissue sarcoma.二噁英、氯痤疮与软组织肉瘤。
Lancet. 1981 Mar 14;1(8220 Pt 1):618-9. doi: 10.1016/s0140-6736(81)92070-5.
3
Lipid abnormalities in workers exposed to dioxin.接触二噁英工人的脂质异常。
Br J Ind Med. 1984 May;41(2):254-6. doi: 10.1136/oem.41.2.254.
4
[Chloracne, porphyria cutanea tarda, and other poisonings due to the herbicides].
Hautarzt. 1976 Jul;27(7):328-33.
5
Blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chemical workers after chloracne and in comparison groups.患氯痤疮的化工工人及对照组的2,3,7,8-四氯二苯并对二恶英血液水平
Int Arch Occup Environ Health. 1991;63(5):325-7. doi: 10.1007/BF00381582.
6
Relationship between clinical and electrophysiological findings and indicators of heavy exposure to 2,3,7,8-tetrachlorodibenzo-dioxin.临床及电生理检查结果与2,3,7,8-四氯二苯并二恶英高暴露指标之间的关系
Scand J Work Environ Health. 1981 Dec;7(4):257-62. doi: 10.5271/sjweh.2553.
7
Serum dioxin, chloracne, and acne in veterans of Operation Ranch Hand.“牧场之手行动”退伍军人的血清二恶英、氯痤疮和痤疮
Arch Environ Health. 1998 May-Jun;53(3):199-204. doi: 10.1080/00039899809605696.
8
The Seveso accident: its nature, extent and consequences.塞维索事故：其性质、范围及后果。
Ann Occup Hyg. 1979;22(4):327-67. doi: 10.1093/annhyg/22.4.327.
9
Mortality experience of employees exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).接触2,3,7,8-四氯二苯并对二恶英（TCDD）的员工的死亡情况
J Occup Med. 1980 Aug;22(8):530-2. doi: 10.1097/00043764-198008000-00009.
10
Health status of workers with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the manufacture of 2,4,5-trichlorophenoxyacetic acid: comparison of findings with and without chloracne.
Am J Ind Med. 1984;5(3):161-82. doi: 10.1002/ajim.4700050303.
引用本文的文献
1
Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho.芳基烃受体与二恶英相关健康危害——油症带来的教训。
Int J Mol Sci. 2021 Jan 12;22(2):708. doi: 10.3390/ijms22020708.
2
The aryl hydrocarbon receptor mediates sex ratio distortion in the embryos sired by TCDD-exposed male mice.二噁英暴露雄性小鼠的精子使胚胎性别比例出现偏差，这一过程由芳香烃受体介导。
Reprod Toxicol. 2020 Jun;94:75-83. doi: 10.1016/j.reprotox.2020.04.072. Epub 2020 Apr 23.
3
Porphyria Diagnostics-Part 1: A Brief Overview of the Porphyrias.卟啉病诊断——第1部分：卟啉病概述
Curr Protoc Hum Genet. 2015 Jul 1;86:17.20.1-17.20.26. doi: 10.1002/0471142905.hg1720s86.
4
A morbidity study of former pentachlorophenol-production workers.一项对 former 五氯苯酚生产工人的发病率研究 。（注：这里“former”翻译为“从前的、曾经的”，感觉语义不太完整，原英文可能表述有误，推测可能是“former pentachlorophenol production workers”，即“从前的五氯苯酚生产工人” ，翻译为“曾从事五氯苯酚生产的工人的发病率研究” 更合适，但按要求严格翻译就是上面的内容 ）
Environ Health Perspect. 1998 Jul;106(7):401-8. doi: 10.1289/ehp.98106401.
5
Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers.在国际癌症研究机构（IARC）针对苯氧基除草剂和氯酚生产工人及喷洒人员开展的扩大队列研究中，二噁英暴露与非肿瘤性死亡率的关系
Environ Health Perspect. 1998 Apr;106 Suppl 2(Suppl 2):645-53. doi: 10.1289/ehp.98106645.
6
Mortality in forestry and construction workers in Finland.芬兰林业和建筑工人的死亡率。
J Epidemiol Community Health. 1993 Dec;47(6):508-9. doi: 10.1136/jech.47.6.508-a.
7
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic storage of retinol in rats with different dietary supplies of vitamin A (retinol).2,3,7,8-四氯二苯并对二恶英对不同维生素A（视黄醇）膳食供应的大鼠肝脏视黄醇储存的影响。
Arch Toxicol. 1980 Oct;45(4):273-85. doi: 10.1007/BF00293808.
8
The pilot Missouri health effect study.密苏里州健康影响试点研究。
Bull Environ Contam Toxicol. 1984 Dec;33(6):662-72. doi: 10.1007/BF01625598.
9
Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans.多氯二苯并二恶英和多氯二苯并呋喃的长期危害。
Environ Health Perspect. 1980 Jun;36:221-40. doi: 10.1289/ehp.8036221.
10
Lipid abnormalities in workers exposed to dioxin.接触二噁英工人的脂质异常。
Br J Ind Med. 1984 May;41(2):254-6. doi: 10.1136/oem.41.2.254.
本文引用的文献
1
INDUSTRIALLY ACQUIRED PORPHYRIA.工业性获得性卟啉病
Arch Dermatol. 1964 Jun;89:793-7. doi: 10.1001/archderm.1964.01590300021006.
2
[Occupational acne (so-called chloracne) due to chlorinated aromatic cyclic ethers].[由氯代芳香环状醚引起的职业性痤疮（所谓的氯痤疮）]
Dermatologica. 1957 Oct;115(4):540-6.
3
2,3,7,8-Tetrachlorodibenzo-p-dioxin: a potent inducer of -aminolevulinic acid synthetase.
Science. 1973 Feb 2;179(4072):476-7. doi: 10.1126/science.179.4072.476.
4
Chloracne from the accidental production of tetrachlorodibenzodioxin.四氯二苯二恶英意外产生导致的氯痤疮。
Br J Ind Med. 1973 Jul;30(3):276-83. doi: 10.1136/oem.30.3.276.
5
Chloracne: three cases.氯痤疮：三例
Proc R Soc Med. 1972 Aug;65(8):687-8. doi: 10.1177/003591577206500810.
6
A health survey of workers in a 2,4-D and 2,4,5-T plan with special attention to chloracne, porphyria cutanea tarda, and psychologic parameters.
Arch Environ Health. 1971 Mar;22(3):316-27. doi: 10.1080/00039896.1971.10665850.
7
Metabolic stability of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin in mammalian liver microsomal systems and in living mice.2,3,7,8-四氯二苯并对二噁英在哺乳动物肝脏微粒体系统及活体小鼠中的代谢稳定性
Arch Environ Contam Toxicol. 1973 Jul;1(2):122-32. doi: 10.1007/BF01986002.
Zotero 插件