Harkin Kenneth R, Andrews Gordon A, Nietfeld Jerome C
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5701, USA.
J Am Vet Med Assoc. 2002 Mar 1;220(5):633-9. doi: 10.2460/javma.2002.220.633.
To determine signalment, history, clinical findings, results of autonomic function testing and other antemortem diagnostic tests, and pathologic findings in dogs with dysautonomia.
Retrospective study.
65 dogs with dysautonomia.
Case records of 68 dogs with a diagnosis of dysautonomia were reviewed; inclusion criteria included histologic confirmation of dysautonomia or clinical signs and results of pharmacologic testing consistent with dysautonomia.
65 dogs fulfilled all criteria for dysautonomia. Dogs from rural environments were overrepresented, and cases of dysautonomia were reported for every month, although the highest number of cases was reported in February and March. Vomiting was the most common clinical sign, followed by diarrhea, signs of anorexia and depression, weight loss, and dysuria. The most common physical examination finding was decreased or absent anal tone, followed by absent pupillary light reflexes and elevated nictitating membrane. Results of pharmacologic testing were consistent with dysautonomia, although no single test was 100% sensitive. Histologic lesions consistent with dysautonomia were found in the autonomic ganglia, brainstem nuclei, and ventral horns of the spinal cord.
Dysautonomia is an endemic disease in Kansas, and a high index of suspicion of the disease can be made by combining clinical signs, physical examination findings, and results of pharmacologic testing.
确定患有自主神经功能障碍的犬只的品种、病史、临床症状、自主神经功能测试及其他生前诊断测试结果，以及病理检查结果。
回顾性研究。
65只患有自主神经功能障碍的犬。
回顾了68只诊断为自主神经功能障碍犬的病例记录；纳入标准包括自主神经功能障碍的组织学确诊或与自主神经功能障碍相符的临床症状及药理测试结果。
65只犬符合自主神经功能障碍的所有标准。来自农村环境的犬占比过高，自主神经功能障碍病例每月均有报告，尽管2月和3月报告的病例数最多。呕吐是最常见的临床症状，其次是腹泻、厌食和抑郁症状、体重减轻及排尿困难。体格检查最常见的发现是肛门张力降低或消失，其次是瞳孔对光反射消失和瞬膜抬高。药理测试结果与自主神经功能障碍相符，尽管没有单一测试是100%敏感的。在自主神经节、脑干核和脊髓腹角发现了与自主神经功能障碍一致的组织学病变。
自主神经功能障碍是堪萨斯州的一种地方病，结合临床症状、体格检查结果和药理测试结果可对该病产生高度怀疑。
