韦尼克脑病的质子磁共振波谱分析
Proton MR spectroscopy of Wernicke encephalopathy.
作者信息
Mascalchi Mario, Belli Giacomo, Guerrini Laura, Nistri Marco, Del Seppia Ines, Villari Natale
机构信息
Department of Clinical Pathophysiology, Radiodiagnostica I, Università di Firenze, Firenze, Italy.
出版信息
AJNR Am J Neuroradiol. 2002 Nov-Dec;23(10):1803-6.
Abstract
Two patients with acute thiamine deficiency were examined with thalamic single-voxel proton MR spectroscopy. T2-weighted images exhibited increased signal intensity. N-acetylaspartate (NAA)/creatine (Cr) ratios were low without detectable lactate. Owing to substantially decreased choline (Cho) T2, the Cho/Cr ratio was not decreased. After thiamine therapy, the NAA/Cr ratio increased, paralleling clinical improvement and reduction in the areas of signal-intensity changes.
摘要
对两名急性硫胺素缺乏患者进行了丘脑单体素质子磁共振波谱检查。T2加权图像显示信号强度增加。N-乙酰天门冬氨酸（NAA）/肌酸（Cr）比值较低，未检测到乳酸。由于胆碱（Cho）的T2显著降低，Cho/Cr比值未降低。硫胺素治疗后，NAA/Cr比值升高，与临床改善及信号强度改变区域的缩小情况平行。
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