Guzek J W, Orlowska-Majdak M, Wdziçzak J
Endokrinologie. 1976 Mar;67(1):36-50.
In dehydrated rats both neurohypophysial hormones diminished in hypothalamus as well as in the neurohypophysis. Oxytocin disappearef from the hypothalamus and neurohypophysis at a more rapid rate than vasopressin did. The minimal content of vasopressin and oxytocin in the hypothalamus was observed during 3rd--4th day, but even in extreme dehydration it was found to be relatively high: 65 per cent of vasopressin and 27 per cent of oxytocin as compared with intact animals. At that time the neurohypophysial vasopressin and oxytocin content were almost fully exhausted. In dehydrated and additionally reserpinized animals (10 mg/kg intraperitoneally, then each 48 hr 5 mg/kg of initial body weight) the vasopressin and and oxytocin hypothalamus and neurohypophysis changed in a similar manner. In some experimental groups the decrease of neurohormones in both sites was more marked under reserpine treatment. The drug seems therefore rather to potentiate the effects of physiological stimulation of osmodetectors. So the existence of monoaminergic stimulatory synapses, directly involved in the neural pathway between the osmodetector and the neurosecretory cell, appears to be hardly probable.
在脱水大鼠中，下丘脑以及神经垂体中的两种神经垂体激素均减少。催产素从下丘脑和神经垂体消失的速度比抗利尿激素更快。抗利尿激素和催产素在下丘脑中的最低含量在第3至4天观察到，但即使在极度脱水时，其含量仍相对较高：与正常动物相比，抗利尿激素为65%，催产素为27%。此时神经垂体中抗利尿激素和催产素的含量几乎完全耗尽。在脱水并额外给予利血平的动物中（腹腔注射10mg/kg，然后每48小时按初始体重给予5mg/kg），下丘脑和神经垂体中抗利尿激素和催产素的变化方式相似。在一些实验组中，利血平处理后两个部位神经激素的减少更为明显。因此，该药物似乎更能增强渗透压感受器生理刺激的作用。所以，直接参与渗透压感受器与神经分泌细胞之间神经通路的单胺能刺激性突触的存在似乎不太可能。
