Marinus Johan, Leentjens Albert F G, Visser Martine, Stiggelbout Anne M, van Hilten Jacobus J
Department of Neurology, Leiden University Medical Center, The Netherlands.
Clin Neuropharmacol. 2002 Nov-Dec;25(6):318-24. doi: 10.1097/00002826-200211000-00008.
The purpose of this study was to evaluate the psychometric properties of the Hospital Anxiety and Depression Scale (HADS) in patients with Parkinson's disease (PD) and to assess the prevalence of symptoms of anxiety and depression in this population. The HADS was sent to 205 patients with PD, together with three quality-of-life (QoL) instruments, i.e. the Parkinson's Disease Questionnaire (PDQ-39), the EQ-5D, and a visual analogue scale (VAS). Hospital Anxiety and Depression Scale scores were also compared with Hoehn-Yahr (H&Y) scores. Eighty-six percent of the patients returned the questionnaires. The quality of the data was good. Cronbach alpha for the HADS was 0.88. Test-retest reliability over 2 weeks was 0.84 for the sum score of the HADS (intraclass correlation coefficient) and ranged from 0.42-0.76 for individual items (weighted kappa). Factor analysis revealed two factors, accounting for 51.9% of the variance. One factor represented anxiety, the other depression. Correlations with PDQ-39, EQ-5D, VAS, and H&Y were 0.72, -0.59, -0.59, and 0.32, respectively (p values < 0.001). Depression scores accounted for 52% of the variance in QoL, whereas disease severity explained 24%. Using the cut-off values proposed by the developers indicated that possible and probable anxiety were present in 29.4% and 19.8% of the patients, respectively. Percentages for possible and probable depression were 21.5 and 16.9. The psychometric performance of the HADS in patients with PD is satisfactory. In addition, almost 50% of the patients displayed symptoms of anxiety, whereas nearly 40% showed signs of depression.
本研究的目的是评估医院焦虑抑郁量表（HADS）在帕金森病（PD）患者中的心理测量特性，并评估该人群中焦虑和抑郁症状的患病率。将HADS与三份生活质量（QoL）量表，即帕金森病问卷（PDQ-39）、EQ-5D和视觉模拟量表（VAS）一起发送给205名PD患者。还将医院焦虑抑郁量表得分与霍恩-亚尔（H&Y）评分进行比较。86%的患者返回了问卷。数据质量良好。HADS的克朗巴赫α系数为0.88。HADS总分的2周重测信度（组内相关系数）为0.84，单个项目的重测信度范围为0.42 - 0.76（加权kappa）。因子分析揭示了两个因子，解释了51.9%的方差。一个因子代表焦虑，另一个代表抑郁。与PDQ-39、EQ-5D、VAS和H&Y的相关性分别为0.72、-0.59、-0.59和0.32（p值<0.001）。抑郁得分占生活质量方差的52%，而疾病严重程度解释了24%。使用开发者提出的临界值表明，分别有29.4%和19.8%的患者存在可能和很可能的焦虑。可能和很可能抑郁的百分比分别为21.5和16.9。HADS在PD患者中的心理测量性能令人满意。此外，近50%的患者表现出焦虑症状，而近40%的患者表现出抑郁迹象。
