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术后复发性胃食管反流的外科治疗结果

Results of surgical treatment for recurrent postoperative gastroesophageal reflux.

作者信息

Braghetto I, Csendes A, Burdiles P, Botero F, Korn O

机构信息

Department of Surgery, Clinical Hospital, University of Chile, Santiago, Chile.

出版信息

Dis Esophagus. 2002;15(4):315-22. doi: 10.1046/j.1442-2050.2002.00274.x.

Abstract

The rate of recurrence of reflux esophagitis after classic antireflux surgery (fundoplication) is 10-15%. This rate is different in patients with esophagitis with and without Barrett's esophagus. We evaluated the clinical and laboratory findings in 104 patients with postoperative recurrent reflux esophagitis, determining the results of repeat antireflux surgery or an acid suppression-bile diversion procedure. Repeat fundoplication was performed in 26 patients, and truncal vagotomy, antrectomy, and Roux-en-Y gastrojejunostomy in 78 patients. Esophagectomy as a third operation was performed in seven patients. After repeat antireflux surgery, endoscopic evaluation demonstrated improvement of esophagitis in a small proportion of patients. Barrett's esophagus remained unchanged, and no regression of ulcer or stricture was observed. These complications improved significantly after acid suppression-bile diversion surgery. Incompetent lower esophageal sphincter (LES) was present in 55.8% after initial surgery and in 23% after reoperation. Acid reflux, initially present in 94.6% of patients, was also observed in 93.6% after fundoplication, 68.8% after redo fundoplication, and 16.6% after treatment with the acid suppression-bile diversion technique. A positive Bilitec test was present in 78% of patients before the operation and 56.6% after the repeat operation, and was negative after bile diversion surgery. Among 13 patients (50%) submitted to repeat surgery alone, esophagectomy as a third operation was necessary as a result of severe non-dilatable stricture in seven patients. Our conclusions are that repeat antireflux surgery alone failed to improve Barrett's esophagus complications and that the best results were obtained in patients submitted to acid suppression-bile diversion surgery.

摘要

经典抗反流手术(胃底折叠术)后反流性食管炎的复发率为10%-15%。在伴有和不伴有巴雷特食管的食管炎患者中,这一复发率有所不同。我们评估了104例术后复发性反流性食管炎患者的临床和实验室检查结果,确定了再次抗反流手术或抑酸-胆汁转流手术的结果。26例患者接受了再次胃底折叠术,78例患者接受了迷走神经干切断术、胃窦切除术和Roux-en-Y胃空肠吻合术。7例患者接受了食管切除术作为第三次手术。再次抗反流手术后,内镜评估显示一小部分患者的食管炎有所改善。巴雷特食管保持不变,未观察到溃疡或狭窄的消退。这些并发症在抑酸-胆汁转流手术后显著改善。初次手术后55.8%的患者存在食管下括约肌(LES)功能不全,再次手术后这一比例为23%。最初94.6%的患者存在酸反流,胃底折叠术后93.6%的患者、再次胃底折叠术后68.8%的患者以及抑酸-胆汁转流技术治疗后16.6%的患者也观察到酸反流。术前78%的患者Bilitec试验呈阳性,再次手术后56.6%的患者呈阳性,胆汁转流手术后呈阴性。在仅接受再次手术的13例患者(50%)中,7例患者因严重不可扩张的狭窄而需要进行食管切除术作为第三次手术。我们的结论是,单独的再次抗反流手术未能改善巴雷特食管并发症,而接受抑酸-胆汁转流手术的患者取得了最佳效果。

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