Fang C T, Hsiung P C, Yu C F, Chen M Y, Wang J D
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC.
Qual Life Res. 2002 Dec;11(8):753-62. doi: 10.1023/a:1020870402019.
We studied the reliability and validity of the World Health Organization quality of life (WHOQOL) assessment instrument in patients with human immunodeficiency virus (HIV) infection. WHOQOL-BREF was used to assess 136 HIV-infected outpatients. The results were analyzed and compared with data from 213 healthy persons. The Cronbach's alpha for internal consistency ranged from 0.74 to 0.85 across domains in HIV-infected patients. The test-retest reliability ranged from 0.64 to 0.79 across domains at average 4-week retest interval. Factor analysis identified four major factors: social, psychological, environment, and physical, consistent with the four domains of the instrument. The scores of all four domains correlated positively with self-evaluated health status and happiness (r range: 0.52-0.60 and 0.55-0.73 across domains, respectively), and correlated negatively with the number and severity of symptoms (r range: -0.40 to -0.47 and -0.41 to -0.52, respectively). The scores of physical, psychological and social domains, but not the environment domain, discriminated between healthy persons and HIV-infected patients (all p < 0.01). We conclude that the WHOQOL-BREF can be a useful quality-of-life instrument in patients with HIV infection.
我们研究了世界卫生组织生活质量（WHOQOL）评估工具在人类免疫缺陷病毒（HIV）感染患者中的可靠性和有效性。采用WHOQOL-BREF对136例HIV感染门诊患者进行评估。对结果进行分析，并与213名健康人的数据进行比较。HIV感染患者各领域的内部一致性Cronbach's α系数在0.74至0.85之间。在平均4周的重测间隔中，各领域的重测信度在0.64至0.79之间。因子分析确定了四个主要因子：社会、心理、环境和生理，与该工具的四个领域一致。所有四个领域的得分均与自我评估的健康状况和幸福感呈正相关（各领域的r范围分别为0.52 - 0.60和0.55 - 0.73），与症状的数量和严重程度呈负相关（r范围分别为 - 0.40至 - 0.47和 - 0.41至 - 0.52）。生理、心理和社会领域的得分能够区分健康人和HIV感染患者，但环境领域得分不能区分（所有p < 0.01）。我们得出结论，WHOQOL-BREF可作为评估HIV感染患者生活质量的有用工具。
