用表达牛瘟病毒融合蛋白基因的重组山羊痘病毒保护牛免受牛瘟和结节性皮肤病侵害。
Protection of cattle against rinderpest and lumpy skin disease with a recombinant capripoxvirus expressing the fusion protein gene of rinderpest virus.
作者信息
Romero C H, Barrett T, Kitching R P, Carn V M, Black D N
机构信息
Institute for Animal Health, Pirbright Laboratory, Woking, Surrey.
出版信息
Vet Rec. 1994 Aug 13;135(7):152-4. doi: 10.1136/vr.135.7.152.
PMID:7880246
Abstract
Cattle were protected against challenge with rinderpest and lumpy skin disease viruses by vaccination with a recombinant capripoxvirus containing the fusion protein (F) gene of rinderpest virus. The minimum protective immunising doses for rinderpest and lumpy skin disease were 5.5 x 10(4) plaque forming units (pfu) and 1.5 x 10(3) pfu, respectively.
摘要
通过用含有牛瘟病毒融合蛋白（F）基因的重组山羊痘病毒进行疫苗接种，牛获得了针对牛瘟和结节性皮肤病病毒攻击的保护。牛瘟和结节性皮肤病的最低保护性免疫剂量分别为5.5×10⁴ 蚀斑形成单位（pfu）和1.5×10³ pfu。
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