Jayasinghe Lalith, Kumarihamy B M Mallika, Jayarathna K H R Nishantha, Udishani N W M Gayathri, Bandara B M Ratnayake, Hara Noriyuki, Fujimoto Yoshinori
Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka.
Phytochemistry. 2003 Feb;62(4):637-41. doi: 10.1016/s0031-9422(02)00623-4.
Antifungal activity guided fractionation of solvent extracts of the stem bark of Bridelia retusa of the family Euphorbiaceae against Cladosporium cladosporioides, furnished new bisabolane sesquiterpenes, (E)-4-(1,5-dimethyl-3-oxo-1-hexenyl)benzoic acid, (E)-4-(1,5-dimethyl-3-oxo-1,4-hexadienyl) benzoic acid, (R)-4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid and (-)-isochaminic acid, together with the known (R)-4-(1,5-dimethyl-3-oxohexyl)benzoic acid (ar-todomatuic acid), 5-allyl-1,2,3-trimethoxybenzene (elemicin), (+)-sesamin and 4-isopropylbenzoic acid (cumic acid). All these compounds showed fungicidal activity on TLC bioautography method at very low concentrations except elemicin.
大戟科余甘子茎皮溶剂提取物对枝孢霉的抗真菌活性导向分离，得到了新的没药烷倍半萜、（E）-4-（1,5-二甲基-3-氧代-1-己烯基）苯甲酸、（E）-4-（1,5-二甲基-3-氧代-1,4-己二烯基）苯甲酸、（R）-4-（1,5-二甲基-3-氧代-4-己烯基）苯甲酸和（-）-异卡米酸，以及已知的（R）-4-（1,5-二甲基-3-氧代己基）苯甲酸（ar-托多米酸）、5-烯丙基-1,2,3-三甲氧基苯（榄香素）、（+）-芝麻素和4-异丙基苯甲酸（枯茗酸）。除榄香素外，所有这些化合物在很低浓度下通过薄层色谱生物自显影法均显示出杀真菌活性。
