Walls Tony, Shankar A G, Shingadia Delane
Academic Department of Child Health, Royal London Hospital, Whitechapel, London, UK.
Lancet Infect Dis. 2003 Feb;3(2):79-86. doi: 10.1016/s1473-3099(03)00515-2.
Adenovirus is increasingly being recognised as a significant pathogen in children following bone marrow transplantation. The virus is endemic in the general paediatric population, and frequently causes severe disease in immunocompromised patients, especially children. Immune responses to adenovirus infection are not fully understood but T-cell responses appear to be important for recovery. Infections can affect a variety of organs with gastrointestinal and urinary tract diseases being the most common. When disseminated infection occurs, reported mortality rates are as high as 60%. The responses to treatment in immunocompromised patients have generally been disappointing. New molecular diagnostic techniques have meant that adenoviral infections can now be detected early, often before symptoms have developed. Clinicians now screen for adenovirus infection to allow early initiation of treatment. It is hoped that this approach, together with effective antiviral therapy, will reduce the deaths from this common virus in high-risk children.
腺病毒越来越被认为是骨髓移植后儿童的一种重要病原体。该病毒在普通儿科人群中呈地方性流行，并且经常在免疫功能低下的患者中引起严重疾病，尤其是儿童。对腺病毒感染的免疫反应尚未完全了解，但T细胞反应似乎对恢复很重要。感染可累及多种器官，其中胃肠道和泌尿系统疾病最为常见。当发生播散性感染时，报告的死亡率高达60%。免疫功能低下患者对治疗的反应通常令人失望。新的分子诊断技术意味着现在可以早期检测到腺病毒感染，通常在症状出现之前。临床医生现在对腺病毒感染进行筛查，以便尽早开始治疗。人们希望这种方法与有效的抗病毒治疗相结合，将减少高危儿童因这种常见病毒导致的死亡。
