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Spread of integron-associated VIM-type metallo-beta-lactamase genes among imipenem-nonsusceptible Pseudomonas aeruginosa strains in Greek hospitals.整合子相关的VIM型金属β-内酰胺酶基因在希腊医院耐亚胺培南铜绿假单胞菌菌株中的传播。
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2
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本文引用的文献

1
bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.在一家韩国医院传播的产金属β-内酰胺酶的铜绿假单胞菌和恶臭假单胞菌分离株中含有bla(VIM-2) 盒的新型整合子
Antimicrob Agents Chemother. 2002 Apr;46(4):1053-8. doi: 10.1128/AAC.46.4.1053-1058.2002.
2
Of Pseudomonas, porins, pumps and carbapenems.关于假单胞菌、孔蛋白、泵和碳青霉烯类抗生素。
J Antimicrob Chemother. 2001 Mar;47(3):247-50. doi: 10.1093/jac/47.3.247.
3
Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase.来自编码VIM-2金属β-内酰胺酶的铜绿假单胞菌质粒的含bla(VIM-2)整合子的分子异质性
FEMS Microbiol Lett. 2001 Feb 20;195(2):145-50. doi: 10.1111/j.1574-6968.2001.tb10512.x.
4
Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.对含有bla(VIM-2)碳青霉烯水解β-内酰胺酶基因的铜绿假单胞菌1类整合子以及两个新型氨基糖苷类耐药基因盒的鉴定。
Antimicrob Agents Chemother. 2001 Feb;45(2):546-52. doi: 10.1128/AAC.45.2.546-552.2001.
5
Carbapenem-hydrolysing VIM-2 metallo- beta-lactamase in Pseudomonas aeruginosa from Greece.希腊铜绿假单胞菌中可水解碳青霉烯类的VIM-2金属β-内酰胺酶
J Antimicrob Chemother. 2000 Dec;46(6):1041-2. doi: 10.1093/jac/46.6.1041.
6
Evaluation of random amplified polymorphic DNA typing of Pseudomonas aeruginosa.铜绿假单胞菌随机扩增多态性DNA分型的评估
J Clin Microbiol. 2000 Dec;38(12):4614-5. doi: 10.1128/JCM.38.12.4614-4615.2000.
7
Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-beta-lactamase.医院内产新型可转移金属β-内酰胺酶VIM-1的耐碳青霉烯铜绿假单胞菌暴发。
Clin Infect Dis. 2000 Nov;31(5):1119-25. doi: 10.1086/317448. Epub 2000 Nov 6.
8
Carbapenemases: a problem in waiting?碳青霉烯酶：一个亟待解决的问题？
Curr Opin Microbiol. 2000 Oct;3(5):489-95. doi: 10.1016/s1369-5274(00)00128-4.
9
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.VIM-2的特性研究，VIM-2是一种可水解碳青霉烯类的金属β-内酰胺酶及其来自法国一株铜绿假单胞菌临床分离株的质粒和整合子携带基因。
Antimicrob Agents Chemother. 2000 Apr;44(4):891-7. doi: 10.1128/AAC.44.4.891-897.2000.
10
Outbreak of infections caused by Pseudomonas aeruginosa producing VIM-1 carbapenemase in Greece.希腊出现由产VIM-1碳青霉烯酶的铜绿假单胞菌引起的感染暴发。
J Clin Microbiol. 2000 Mar;38(3):1290-2. doi: 10.1128/JCM.38.3.1290-1292.2000.

整合子相关的VIM型金属β-内酰胺酶基因在希腊医院耐亚胺培南铜绿假单胞菌菌株中的传播。

Spread of integron-associated VIM-type metallo-beta-lactamase genes among imipenem-nonsusceptible Pseudomonas aeruginosa strains in Greek hospitals.

作者信息

Giakkoupi P, Petrikkos G, Tzouvelekis L S, Tsonas S, Legakis N J, Vatopoulos A C

机构信息

Department of Hygiene & Epidemiology, Medical School, Athens University, Greece.

出版信息

J Clin Microbiol. 2003 Feb;41(2):822-5. doi: 10.1128/JCM.41.2.822-825.2003.

DOI:10.1128/JCM.41.2.822-825.2003
PMID:12574292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC149675/
Abstract

Fifty-eight imipenem-nonsusceptible (MIC >or= 8 microg/ml) Pseudomonas aeruginosa strains isolated during May 2001 in 15 Greek hospitals were studied. Thirty-six isolates derived from nine hospitals carried VIM-type metallo-beta-lactamase genes, as found by PCR. In 34 isolates, bla(VIM) was associated with class 1 integrons of various sizes. DNA sequencing indicated the presence of bla(VIM-2) gene cassettes in a variety of integron structures. Random amplified polymorphic DNA typing suggested diversity of the bla(VIM)-positive strains. Synergy between 2-mercaptoacetic acid and imipenem indicated carbapenemase activity in 26 bla(VIM)-positive strains.

摘要

对2001年5月在希腊15家医院分离出的58株对亚胺培南不敏感（MIC≥8μg/ml）的铜绿假单胞菌菌株进行了研究。通过PCR发现，来自9家医院的36株分离菌携带VIM型金属β-内酰胺酶基因。在34株分离菌中，bla(VIM)与各种大小的1类整合子相关。DNA测序表明在多种整合子结构中存在bla(VIM-2)基因盒。随机扩增多态性DNA分型表明bla(VIM)阳性菌株具有多样性。2-巯基乙酸与亚胺培南之间的协同作用表明26株bla(VIM)阳性菌株具有碳青霉烯酶活性。