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白细胞介素12在一定程度上调节问号钩端螺旋体刺激的人全血中γ干扰素的释放。

Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans.

作者信息

de Fost Maaike, Hartskeerl Rudy A, Groenendijk Martijn R, van der Poll Tom

机构信息

Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Clin Diagn Lab Immunol. 2003 Mar;10(2):332-5. doi: 10.1128/cdli.10.2.332-335.2003.

DOI:10.1128/cdli.10.2.332-335.2003
PMID:12626464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC150539/
Abstract

Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-gamma) and the IFN-gamma-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-gamma was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

摘要

热灭活的致病性问号钩端螺旋体赖型菌株在体外可诱导人全血产生γ干扰素（IFN-γ）以及诱导IFN-γ产生的细胞因子白细胞介素-12p40（IL-12p40）和肿瘤坏死因子α。IFN-γ的产生很大程度上依赖于IL-12。这些数据表明致病性钩端螺旋体能刺激参与细胞免疫的I型细胞因子的产生。

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Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and gammadelta T lymphocytes.保护性灭活波摩那钩端螺旋体疫苗可诱导由CD4和γδ T淋巴细胞介导的强大的Th1免疫反应。
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