Alawa C B I, Adamu A M, Gefu J O, Ajanusi O J, Abdu P A, Chiezey N P, Alawa J N, Bowman D D
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Parasitol. 2003 Apr 2;113(1):73-81. doi: 10.1016/s0304-4017(03)00040-2.
Vernonia amygdalina and Annona senegalensis, two plants used by local/smallholder livestock farmers in Nigeria as anthelmintic were screened for in vitro anthelmintic activity using Haemonchus contortus eggs. The extract of V. amygdalina did not show any significant activity at concentrations up to 11.2mg/ml. The extract of A. senegalensis showed significant (P<0.001) reduction in egg hatch at a concentration of 7.1mg/ml. The in vitro fecal culture of eggs with A. senegalensis showed significant (P<0.001) reductions in larval recovery with increasing concentrations from 1 to 10% ((w/w) in fecal culture) when whole ground plant material was used. Although traditional veterinary healers and local livestock farmers claim both plants are effective as anthelmintics, our result indicate that only A. senegalensis showed promising anthelmintic activity especially with use of ground whole plant materials as used by some farmers.
对在尼日利亚被当地/小农户用作驱虫剂的两种植物——苦叶（Vernonia amygdalina）和塞内加尔番荔枝（Annona senegalensis），使用捻转血矛线虫（Haemonchus contortus）虫卵进行了体外驱虫活性筛选。在浓度高达11.2mg/ml时，苦叶提取物未显示出任何显著活性。塞内加尔番荔枝提取物在浓度为7.1mg/ml时，显示出显著（P<0.001）的虫卵孵化率降低。当使用整株磨碎的植物材料时，用塞内加尔番荔枝进行虫卵的体外粪便培养显示，随着粪便培养中浓度从1%增加到10%（w/w），幼虫回收率显著（P<0.001）降低。尽管传统兽医和当地养殖户声称这两种植物都是有效的驱虫剂，但我们的结果表明，只有塞内加尔番荔枝显示出有前景的驱虫活性，特别是在使用一些农户所采用的整株磨碎植物材料时。
