番荔枝种子中的驱虫产乙酸素
Anthelmintic acetogenin from Annona squamosa L. Seeds.
作者信息
Souza Marta M C, Bevilaqua Claudia M L, Morais Selene M, Costa Cícero T C, Silva Ana R A, Braz-Filho Raimundo
机构信息
Laboratório de Doenças Parasitárias, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
出版信息
An Acad Bras Cienc. 2008 Jun;80(2):271-7. doi: 10.1590/s0001-37652008000200005.
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.
番荔枝种子提取物对巴西东北部绵羊和山羊的主要线虫捻转血矛线虫显示出驱虫活性。从乙酸乙酯提取物中分离出一种化合物1，其在25 mg ml(-1)时可抑制捻转血矛线虫的虫卵孵化。基于光谱分析，确定1的结构为一种C37三羟基邻位双四氢呋喃产乙酸素。
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