低亲和力抗体在免疫复合物疾病中的作用。NZB/W F1杂交小鼠中抗DNA抗体的数量。
The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice.
作者信息
Steward M W, Katz F E, West N J
出版信息
Clin Exp Immunol. 1975 Jul;21(1):121-30.
Abstract
The level and avidity of anti-DNA antibody in the serum of New Zealand Black/White (NZB/W F1) hybrid mice has been determined. The results show that there is an age and sex-related variation in the avidity of this antibody. In mice of both sexes, the avidity of circulating anti-DNA antibody increases up to 5 months of age; thereafter the avidity falls with increasing age. These variations are more marked in males, but female mice consistently have lower avidity anti-DNA antibody than males. Thus the time of onset, time course and severity of the murine lupus syndrome in NZB/W F1 mice are associated with the presence of increasing levels of low avidity anti-DNA antibody in the serum. These results are discussed in the context of the possible role of low avidity antibody in immune complex disease.
摘要
已测定了新西兰黑/白（NZB/W F1）杂交小鼠血清中抗DNA抗体的水平和亲和力。结果表明，该抗体的亲和力存在与年龄和性别相关的差异。在两性小鼠中，循环抗DNA抗体的亲和力在5月龄前升高；此后，随着年龄增长亲和力下降。这些差异在雄性小鼠中更为明显，但雌性小鼠的抗DNA抗体亲和力始终低于雄性。因此，NZB/W F1小鼠中鼠类狼疮综合征的发病时间、病程和严重程度与血清中低亲和力抗DNA抗体水平的升高有关。本文结合低亲和力抗体在免疫复合物疾病中可能发挥的作用对这些结果进行了讨论。
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