Djibuti M, Shakarishvili R
Department of Public Health and Epidemiology, State Medical Academy, 380079 Tbilisi, Georgia.
J Neurol Neurosurg Psychiatry. 2003 May;74(5):570-3. doi: 10.1136/jnnp.74.5.570.
To identify the clinical, demographic, and socioeconomic factors that are associated with a poor quality of life in patients with epilepsy in Georgia.
Clinical, demographic, and socioeconomic status data were collected from 115 adult epileptic outpatients being treated in the epilepsy programme at the Sarajishvili Institute of Neurology and Neurosurgery (SINN) in Tbilisi, Georgia. Health Related Quality of Life (HRQL) was measured by the Quality of Life in Epilepsy Inventory (QOLIE-31). Multiple regression analysis was used to determine which variables were associated with QOLIE-31 total and subcomponent scores.
Mean age of the patient population was 37.9 (SD 15.8) years; 43.5% were females; 51.8% did not have a partner; 39.1% had some university education; 82.6% were unemployed. Of 115 epileptic patients 83.3% had partial, and 16.7% had generalised seizures. Overall, 32.2% of patients were seizure free, and 28.7% experienced more than 10 seizures over the past year. The variables that most strongly predicted a lower QOLIE-31 total score were a low education level, high seizure frequency, and long duration of epilepsy. The QOLIE-31 all subcomponent scores correlated strongly with seizure frequency. Advanced age was a significant predictor for a low overall quality of life, energy/fatigue, and cognitive scores. Female sex was the factor that significantly predicted a low seizure worry score. Education level strongly correlated with overall quality of life, and cognitive and social functioning scores.
Clinical factors such as high seizure frequency and long duration of epilepsy had a significant influence on HRQL. Advanced age, female sex, and a low education level were the demographic factors that correlated strongly with low quality of life scores.
确定与格鲁吉亚癫痫患者生活质量差相关的临床、人口统计学和社会经济因素。
收集了格鲁吉亚第比利斯萨拉吉什维利神经学与神经外科学研究所（SINN）癫痫项目中接受治疗的115名成年癫痫门诊患者的临床、人口统计学和社会经济状况数据。采用癫痫生活质量量表（QOLIE - 31）测量健康相关生活质量（HRQL）。使用多元回归分析确定哪些变量与QOLIE - 31总分及子成分得分相关。
患者群体的平均年龄为37.9（标准差15.8）岁；43.5%为女性；51.8%没有伴侣；39.1%接受过一些大学教育；82.6%失业。在115名癫痫患者中，83.3%患有部分性发作，16.7%患有全身性发作。总体而言，32.2%的患者无癫痫发作，28.7%的患者在过去一年中癫痫发作超过10次。最能预测较低QOLIE - 31总分的变量是低教育水平、高癫痫发作频率和癫痫持续时间长。QOLIE - 31所有子成分得分与癫痫发作频率密切相关。高龄是总体生活质量低、精力/疲劳及认知得分低的显著预测因素。女性是癫痫发作担忧得分低的显著预测因素。教育水平与总体生活质量、认知和社会功能得分密切相关。
癫痫发作频率高和癫痫持续时间长等临床因素对健康相关生活质量有显著影响。高龄、女性和低教育水平是与低生活质量得分密切相关的人口统计学因素。
