Wang Fu-Li, Gu Xiang-Min, Hao Bao-Yun, Wang Shan, Chen Ze-Jie, Ding Cheng-Yun
Department of Hospital Management, First Affiliated Hospital, General Hospital of People's Liberation Army, Beijing 100048, China.
Department of Programmed Immunization, Center for Disease Control and Prevention of Tianjin Binhai New Area, Tianjin 300450, China.
Chin Med J (Engl). 2017;130(1):83-87. doi: 10.4103/0366-6999.196572.
Epilepsy is a chronic disorder characterized by recurrent seizures and has significant psychological and social consequence for everyday living. Epilepsy affects various aspects of ones' social life. The present study aimed to investigate the influence of marital status on the quality of life of adult Chinese patients with epilepsy.
This study surveyed 805 Chinese adults who have been clinically diagnosed with epilepsy for longer than 1 year in 11 hospitals in Beijing. In this survey, 532 (66.1%) participants were married. All of them completed the case report form with enquiries on demographic data, social factors, and illness. The marriage status of adult epileptic quality of life was the dependent variable, and demographic data and clinical data were independent variables, analyzed through the multiple linear regression analysis methods. The patients' quality of life was assessed using the Quality of Life in patients with Epilepsy-31 items (QOLIE-31) questionnaire, the Patient Health Questionnaire-9 items (PHQ-9), and the Generalized Anxiety Disorder-7 items (GAD-7).
The PHQ-9 and GAD-7 scores in the unmarried group (PHQ-9 = 6.0 and GAD-7 = 5.0) were significantly higher than that of the married group (PHQ-9 = 4.0 and GAD-7 =3.0). The scores of married adult patients with epilepsy on QOLIE (61.8 ± 15.3) and social function (70.9 ± 22.7) were higher than the scores of the unmarried patients aged between 20 and 44 years. The scores of married adult epileptics on the QOLIE (58.4 ± 14.6) and the energy/fatigue (62.1 ± 20.4) were higher than the scores of the unmarried patients (QOLIE = 58.4 ± 14.6 and the energy/fatigue = 62.1 ± 20.4) aged between 45 and 59 years. For the adult epilepsy patients, depression, anxiety, seizures within the last year, disease course, medical expense category, and marriage* age are negatively correlated with the quality of life. Occupation, educational level, and average monthly income are closely related to the quality of life.
Married adult epileptic patients have better quality of life than that of unmarried adult patients in young and middle-aged age groups. Unmarried adult patients with epilepsy are more anxious and depressed than married adult patients.
癫痫是一种以反复发作性癫痫发作为特征的慢性疾病，对日常生活有着重大的心理和社会影响。癫痫会影响患者社会生活的各个方面。本研究旨在调查婚姻状况对成年中国癫痫患者生活质量的影响。
本研究对北京11家医院中805名临床诊断为癫痫且病程超过1年的中国成年人进行了调查。在此次调查中，532名（66.1%）参与者已婚。他们均填写了病例报告表，内容包括人口统计学数据、社会因素和疾病情况。将成年癫痫患者的生活质量作为因变量，人口统计学数据和临床数据作为自变量，采用多元线性回归分析方法进行分析。使用癫痫患者生活质量-31项问卷（QOLIE-31）、患者健康问卷-9项（PHQ-9）和广泛性焦虑障碍-7项问卷（GAD-7）对患者的生活质量进行评估。
未婚组的PHQ-9和GAD-7得分（PHQ-9 = 6.0，GAD-7 = 5.0）显著高于已婚组（PHQ-9 = 4.0，GAD-7 = 3.0）。20至44岁的已婚成年癫痫患者在QOLIE（61.8±15.3）和社会功能（70.9±22.7）方面的得分高于未婚患者。45至59岁的已婚成年癫痫患者在QOLIE（58.4±14.6）和精力/疲劳（62.1±20.4）方面的得分高于未婚患者（QOLIE = 58.4±14.6，精力/疲劳 = 62.1±20.4）。对于成年癫痫患者，抑郁、焦虑、过去一年的癫痫发作次数、病程、医疗费用类别以及婚姻*年龄与生活质量呈负相关。职业、教育水平和月平均收入与生活质量密切相关。
在中青年年龄组中，已婚成年癫痫患者的生活质量优于未婚成年患者。未婚成年癫痫患者比已婚成年患者更焦虑和抑郁。
