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来自铜绿假单胞菌整合子的新型3-N-氨基糖苷乙酰转移酶基因aac(3)-Ic

Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.

作者信息

Riccio Maria Letizia, Docquier Jean-Denis, Dell'Amico Emanuela, Luzzaro Francesco, Amicosante Gianfranco, Rossolini Gian Maria

机构信息

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena, Italy.

出版信息

Antimicrob Agents Chemother. 2003 May;47(5):1746-8. doi: 10.1128/AAC.47.5.1746-1748.2003.

DOI:10.1128/AAC.47.5.1746-1748.2003
PMID:12709352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153335/
Abstract

A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla(VIM-2) and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.

摘要

一个编码AAC(3)-I氨基糖苷3-N-乙酰基转移酶的新基因aac(3)-Ic，在插入铜绿假单胞菌整合子的一个基因盒上被鉴定出来，该整合子还携带bla(VIM-2)和cmlA7基因盒。aac(3)-Ic基因产物分别与AAC(3)-Ia和AAC(3)-Ib有59%和57%的同一性，并赋予对庆大霉素和西索米星的抗性。

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