Stokland Eira, Andréasson Svenerik, Jacobsson Bo, Jodal Ulf, Ljung Barbro
Department of Paediatric Radiology and Clinical Physiology, The Queen Silvia Children's Hospital, 41685 Gothenburg, Sweden.
Pediatr Radiol. 2003 Apr;33(4):247-9. doi: 10.1007/s00247-003-0874-0. Epub 2003 Feb 22.
Sedation with midazolam facilitates the performance of diagnostic procedures in children, including voiding cystourethrography (VCUG). However, the influence of sedation on voiding and imaging results have not been adequately evaluated.
Midazolam and placebo were compared to assess discomfort during VCUG and to evaluate if sedation influenced the outcome of the examination.
The study was prospective, randomised and double-blind, and included 95 children, 48 in the midazolam group (median age 2.2 years) and 47 in the placebo group (median age 3.2 years). The evaluation included the child's/parent's experience of the VCUG, as well as the examination results.
The children/parents in the midazolam group experienced the VCUG as less distressing compared to those in the placebo group ( P<0.001). Forty-six of 48 children sedated with midazolam could void during the imaging procedure compared to 38 of 47 children given placebo ( NS). There was no difference in frequency or grade of vesicoureteric reflux or bladder emptying between the groups.
When sedation is required to perform VCUG in children, midazolam can be used without negative effect on the outcome of the examination.
咪达唑仑镇静有助于儿童进行诊断性操作，包括排尿性膀胱尿道造影（VCUG）。然而，镇静对排尿及成像结果的影响尚未得到充分评估。
比较咪达唑仑与安慰剂，以评估VCUG过程中的不适情况，并评估镇静是否会影响检查结果。
本研究为前瞻性、随机、双盲研究，纳入95名儿童，咪达唑仑组48名（中位年龄2.2岁），安慰剂组47名（中位年龄3.2岁）。评估内容包括儿童/家长对VCUG的体验以及检查结果。
与安慰剂组相比，咪达唑仑组儿童/家长感觉VCUG的痛苦程度更低（P<0.001）。咪达唑仑镇静的48名儿童中有46名在成像过程中能够排尿，而给予安慰剂的47名儿童中有38名能够排尿（无统计学差异）。两组间输尿管膀胱反流的频率或分级以及膀胱排空情况均无差异。
当需要对儿童进行VCUG镇静时，可使用咪达唑仑，且对检查结果无负面影响。
