中心性浆液性脉络膜视网膜病变中脉络膜循环异常的特征。
Features of abnormal choroidal circulation in central serous chorioretinopathy.
作者信息
Kitaya N, Nagaoka T, Hikichi T, Sugawara R, Fukui K, Ishiko S, Yoshida A
机构信息
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan.
出版信息
Br J Ophthalmol. 2003 Jun;87(6):709-12. doi: 10.1136/bjo.87.6.709.
AIMS
To evaluate abnormalities in the choroidal circulation in cases of central serous chorioretinopathy (CSC).
METHODS
A complete clinical ophthalmological examination was performed using simultaneous fluorescein and indocyanine green (ICG) angiography with a confocal scanning laser ophthalmoscopy and the digital images analysed in 36 consecutive patients with acute CSC. To quantify the choroidal circulation, the foveal choroidal blood flow was measured in 11 patients using laser Doppler flowmetry.
RESULTS
Fluorescein angiography showed focal leakage from the retinal pigment epithelium in all patients. ICG angiography revealed delays in arterial filling in 27 eyes (75%), and fluorescein angiography showed small hypofluorescent points around the leakage in 27 eyes (75%). Abnormal choroidal hyperfluorescence was observed in 30 eyes (83%). The choroidal blood flow in eyes with CSC was 45% lower than in fellow eyes (p<0.01).
CONCLUSION
Decreased choroidal blood flow in CSC was demonstrated for the first time. The decreased choroidal blood flow might be correlated with the small, localised hypofluorescent areas, which may indicate non-perfused areas of the choriocapillaris that are frequently seen during ICG angiography.
目的
评估中心性浆液性脉络膜视网膜病变（CSC）患者脉络膜循环的异常情况。
方法
对36例急性CSC患者使用共焦扫描激光眼底镜同时进行荧光素和吲哚菁绿（ICG）血管造影进行完整的临床眼科检查，并对数字图像进行分析。为了量化脉络膜循环，使用激光多普勒血流仪对11例患者测量了黄斑区脉络膜血流。
结果
荧光素血管造影显示所有患者视网膜色素上皮均有局灶性渗漏。ICG血管造影显示27只眼（75%）动脉充盈延迟，荧光素血管造影显示27只眼（75%）渗漏周围有小的低荧光点。30只眼（83%）观察到脉络膜异常高荧光。CSC患者患眼的脉络膜血流比健眼低45%（p<0.01）。
结论
首次证实CSC患者脉络膜血流减少。脉络膜血流减少可能与小的局限性低荧光区相关，这些低荧光区可能提示脉络膜毛细血管无灌注区，这在ICG血管造影中经常可见。
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