Freeman W R, Bartsch D U, Mueller A J, Banker A S, Weinreb R N
Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla 92093-0946, USA.
Arch Ophthalmol. 1998 Apr;116(4):455-63. doi: 10.1001/archopht.116.4.455.
Fluorescein and indocyanine green (ICG) angiography are both useful in the diagnosis and treatment of many retinal diseases. In some cases, both tests must be performed for diagnosis and treatment; however, performing both is time-consuming and may require multiple injections.
We designed a compact digital confocal scanning laser ophthalmoscope to perform true simultaneous fluorescein and ICG angiography. We report our experience using the instrument to perform 169 angiograms in 117 patients.
There were no unexpected adverse effects from mixing the dyes and administering them in 1 injection. An entire examination, including fundus photography, fluorescein angiography, and ICG angiography, could be performed in 45 minutes. It was possible to study differences in fluorescein patterns by comparing identically timed frames and to find cases in which ICG or fluorescein was optimal in visualizing retinal and subretinal structures. Confocal optical sections in the depth (z) dimension allowed viewing in different planes. It was possible to overlay ICG and fluorescein images or compare them side-by-side using a linked cursor. Digital transmission of the images was also performed.
Simultaneous ICG and fluorescein angiography can be performed rapidly, safely, and conveniently. The availability of simultaneous angiography will allow critical determination of the relative advantages and disadvantages of both types of angiography.
荧光素血管造影和吲哚菁绿（ICG）血管造影在许多视网膜疾病的诊断和治疗中都很有用。在某些情况下，为了诊断和治疗必须同时进行这两项检查；然而，两项检查都进行既耗时，而且可能需要多次注射。
我们设计了一种紧凑型数字共焦扫描激光眼科显微镜，以实现真正的荧光素和ICG同步血管造影。我们报告了使用该仪器为117例患者进行169次血管造影的经验。
将两种染料混合并一次注射给药未出现意外不良反应。包括眼底照相、荧光素血管造影和ICG血管造影在内的整个检查可在45分钟内完成。通过比较相同时间的图像帧，可以研究荧光素图像模式的差异，并发现ICG或荧光素在显示视网膜和视网膜下结构方面最具优势的病例。深度（z）维度的共焦光学切片允许在不同平面上观察。可以叠加ICG和荧光素图像，或使用联动光标并排比较它们。图像还进行了数字传输。
ICG和荧光素同步血管造影可以快速、安全且方便地进行。同步血管造影的应用将有助于明确判定这两种血管造影各自的相对优缺点。
