Fredkin D R, Rice J A
Department of Physics, University of California, San Diego, La Jolla 92093.
Proc Biol Sci. 1992 Aug 22;249(1325):125-32. doi: 10.1098/rspb.1992.0094.
We present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more difficult. We present examples in which the rate constants can be effectively estimated and examples in which they cannot.
我们提出了一种用于分析来自单通道膜片钳的噪声采样数据的方法，该方法绕过了理想化量子信号的恢复。我们表明，即使在没有特定模型的情况下，也可以估计电导水平以及这些水平内的平均驻留时间。估计假设动力学方案的速率常数则更为困难。我们给出了可以有效估计速率常数的示例以及无法估计速率常数的示例。
