iSPOT：一种用于推断蛋白质模块家族相互作用特异性的网络工具。
iSPOT: A web tool to infer the interaction specificity of families of protein modules.
作者信息
Brannetti Barbara, Helmer-Citterich Manuela
机构信息
Centre for Molecular Bioinformatics, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
出版信息
Nucleic Acids Res. 2003 Jul 1;31(13):3709-11. doi: 10.1093/nar/gkg592.
Abstract
iSPOT (http://cbm.bio.uniroma2.it/ispot) is a web tool developed to infer the recognition specificity of protein module families; it is based on the SPOT procedure that utilizes information from position-specific contacts, derived from the available domain/ligand complexes of known structure, and experimental interaction data to build a database of residue-residue contact frequencies. iSPOT is available to infer the interaction specificity of PDZ, SH3 and WW domains. For each family of protein domains, iSPOT evaluates the probability of interaction between a query domain of the specified families and an input protein/peptide sequence and makes it possible to search for potential binding partners of a given domain within the SWISS-PROT database. The experimentally derived interaction data utilized to build the PDZ, SH3 and WW databases of residue-residue contact frequencies are also accessible. Here we describe the application to the WW family of protein modules.
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本文引用的文献
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iSPOT: a web tool for the analysis and recognition of protein domain specificity.iSPOT：一种用于分析和识别蛋白质结构域特异性的网络工具。
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