摄入富含原花青素的葡萄籽提取物后，在人体血清中检测到原花青素B1。
Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.
作者信息
Sano Atsushi, Yamakoshi Jun, Tokutake Shoichi, Tobe Koichiro, Kubota Yoshiro, Kikuchi Mamoru
机构信息
Research and Development Division, Kikkoman Corporation, 399 Noda, Noda, Chiba 278-0037, Japan.
出版信息
Biosci Biotechnol Biochem. 2003 May;67(5):1140-3. doi: 10.1271/bbb.67.1140.
To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and beta-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4beta-->8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 +/- 2.5 nmol/l.
为证实原花青素（PA）能被人体吸收，对4名健康成年人给予2.0克富含PA的葡萄籽提取物（GSE）。在摄入前和摄入后2小时采集血液。通过硫酸酯酶和β-葡萄糖醛酸酶的酶处理，采用高效液相色谱-质谱联用（LC/MS）对血样进行分析。摄入后2小时在人血清中检测到原花青素B1 [表儿茶素-（4β→8）-儿茶素]。其浓度为10.6±2.5纳摩尔/升。
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