Nakaji S, Yoshioka Y, Mashiko T, Yamamoto Y, Kojima A, Baxter G D, Sugawara K
Department of Hygiene. Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki 036-8562, Japan.
Eur J Epidemiol. 2003;18(5):381-3. doi: 10.1023/a:1024265411218.
The prevalence of cigarette smoking among Japanese men has been consistently high compared with Western males over the past 30 years. However, during the same period, the incidence of and mortality rates for lung cancer have consistently been lower in Japan than in Western countries ('Japanese smoking paradox'). The odds ratio/relative risk of cigarette smoking for lung cancer mortality/incidence relative to the same number of cigarettes smoked per capita in Japan, were apparently lower than those in Western countries. This must be the cause driving the 'Japanese smoking paradox'. Furthermore, low carcinogenic ingredients in Japanese cigarettes and a congenitally-related resistance to smoking-related lung carcinogenesis emerged as the main factors which have brought the 'Japanese smoking paradox'.
在过去30年里,与西方男性相比,日本男性吸烟率一直居高不下。然而,在同一时期,日本肺癌的发病率和死亡率一直低于西方国家(“日本吸烟悖论”)。相对于日本人均吸烟量相同的情况,吸烟导致肺癌死亡/发病的优势比/相对风险明显低于西方国家。这必定是导致“日本吸烟悖论”的原因。此外,日本香烟中致癌成分含量低以及先天性的与吸烟相关的肺癌发生抗性,成为导致“日本吸烟悖论”的主要因素。