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实验动物疼痛的物种特异性评估。

Species-specific assessment of pain in laboratory animals.

作者信息

Stasiak Karen L, Maul Don, French Elisa, Hellyer Peter W, VandeWoude Sue

机构信息

Department of Pathology, Veterinary Teaching Hospital, Colorado State University, Fort Collins, CO 80523-1682, USA.

出版信息

Contemp Top Lab Anim Sci. 2003 Jul;42(4):13-20.

PMID:12906396
Abstract

Pain has been defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with actual or potential damage or described in terms of such damage". However, the ability to describe the concept of pain is difficult largely because pain is an individualized and subjective experience. What one person finds painful, another may not; what relieves pain for one may not do so for another. Awareness of pain management has become an important health issue for humans and animals. To effectively manage pain, it is crucial to be able to identify it, and identification of pain in animals can be especially problematic. Recognition and alleviation of pain in animals used in biomedical research and teaching is an important goal, both from a humane and regulatory perspective. This paper will: 1) review current literature regarding pain assessment using pain scales and 2) describe how an institutional care and use committee (IACUC) has implemented an effective pain scoring system to allow for an objective, accurate, and humane assessment of pain experienced by animals used in biomedical research.

摘要

国际疼痛研究协会将疼痛定义为“一种与实际的或潜在的组织损伤相关联的,或者用此类损伤来描述的不愉快的感觉和情感体验”。然而,描述疼痛概念的能力很大程度上存在困难,这主要是因为疼痛是一种个体化的主观体验。一个人觉得疼痛的事情,另一个人可能并不觉得;一种能缓解某个人疼痛的方法,对另一个人可能并不起作用。疼痛管理意识已成为人类和动物的一个重要健康问题。为了有效管理疼痛,能够识别疼痛至关重要,而识别动物的疼痛可能尤其成问题。从人道和监管的角度来看,识别和减轻用于生物医学研究和教学的动物的疼痛是一个重要目标。本文将:1)回顾当前有关使用疼痛量表进行疼痛评估的文献,以及2)描述一个机构的动物护理和使用委员会(IACUC)如何实施一个有效的疼痛评分系统,以便对用于生物医学研究的动物所经历的疼痛进行客观、准确且人道的评估。

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