Tei Shuchin, Kitajima Naoto, Takahashi Kazuaki, Mishiro Shunji
Department of Internal medicine, Kasai City Hospital, Hyogo, Japan.
Lancet. 2003 Aug 2;362(9381):371-3. doi: 10.1016/S0140-6736(03)14025-1.
Zoonosis has been suggested for hepatitis E virus (HEV) infection, but so far is based only on indirect evidence. We experienced a series of cases of HEV infection among people who had eaten uncooked deer meat 6-7 weeks before. On testing, a left over portion of the deer meat, kept frozen to eat in the future, was positive for HEV RNA, whose nucleotide sequence was identical to those from the patients. Patients' family members who ate none or very little of the deer meat remained uninfected. These findings provide direct evidence for HEV infection to be a zoonosis.
有人提出戊型肝炎病毒（HEV）感染属于人畜共患病，但目前仅基于间接证据。我们遇到了一系列在6至7周前食用过生鹿肉的人感染戊型肝炎病毒的病例。检测时，未来留作食用而冷冻保存的一部分剩余鹿肉，其戊型肝炎病毒核糖核酸呈阳性，其核苷酸序列与患者的核苷酸序列相同。未食用或极少食用鹿肉的患者家庭成员未被感染。这些发现为戊型肝炎病毒感染是人畜共患病提供了直接证据。
