来自朝鲜白连翘叶片的四种对血管紧张素转换酶具有抑制作用的糖苷。

Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme.

作者信息

Oh Hyuncheol, Kang Dae-Gill, Kwon Tae-Oh, Jang Kyu Kwan, Chai Kyu-Yun, Yun Young-Gab, Chung Hun-Taeg, Lee Ho-Sub

机构信息

Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea.

出版信息

Phytother Res. 2003 Aug;17(7):811-3. doi: 10.1002/ptr.1199.

DOI:10.1002/ptr.1199

PMID:12916084

Abstract

The bioassay-guided fractionation of the n-BuOH extract of Abeliophyllum distichum afforded acteoside (1), isoacteoside (2), rutin (3), and hirsutrin (4). Compounds 1-3 moderately inhibited the angiotensin I converting enzyme activity in a dose-dependent manner. Compounds 1-3 showed the 50% inhibitory concentration values of 228 micro g/mL, 290 micro g/mL, and 278 micro g/mL, respectively.

摘要

对朝鲜白鹃梅正丁醇提取物进行生物活性导向的分离，得到了毛蕊花糖苷（1）、异毛蕊花糖苷（2）、芦丁（3）和水苏糖苷（4）。化合物1 - 3以剂量依赖性方式适度抑制血管紧张素I转化酶活性。化合物1 - 3的半数抑制浓度值分别为228微克/毫升、290微克/毫升和278微克/毫升。