Chakeres Donald W, Bornstein Robert, Kangarlu Allahyar
Department of Radiology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA.
J Magn Reson Imaging. 2003 Sep;18(3):342-5. doi: 10.1002/jmri.10366.
To discover whether there was a measurable alteration in cognitive performance in humans when exposed to a static magnetic field of 8 Tesla (T).
Twenty-five normal human subjects were evaluated at both 0.05 and 8 T in a randomized order. Six standardized neuropsychological tests were administered and auditory reaction times were assessed. The cognitive assessment included measures of learning and retention, verbal fluency (spontaneous word generation), auditory attention, and auditory working memory. Alternate test forms were utilized to reduce practice effects. The sequential order of testing, 0.05 T first vs. 8 T first exposure, was randomized. The data was analyzed using univariate comparisons for correlated means to assess potential differences under the two conditions.
There were no clinically significant differences in any of the measures. On a measure of recognition memory the subjects performed significantly better in the 0.05T condition, but the difference was extremely small, not clinically meaningful, and likely due to statistical artifact.
This study shows that exposure of the brain to high magnetic fields of up to 8 T does not appear to alter human cognitive performance.
探究人类暴露于8特斯拉（T）静磁场时认知能力是否会发生可测量的变化。
25名正常人类受试者以随机顺序在0.05 T和8 T两种条件下接受评估。进行了六项标准化神经心理学测试，并评估了听觉反应时间。认知评估包括学习与记忆、语言流畅性（自发单词生成）、听觉注意力和听觉工作记忆等方面的测量。采用交替测试形式以减少练习效应。测试的顺序，即先在0.05 T还是先在8 T条件下暴露，是随机的。使用相关均值的单变量比较分析数据，以评估两种条件下的潜在差异。
各项测量指标均无临床显著差异。在一项识别记忆测量中，受试者在0.05 T条件下表现明显更好，但差异极小，无临床意义，可能是统计假象所致。
本研究表明，大脑暴露于高达8 T的强磁场中似乎不会改变人类的认知能力。
