Sabchareon A, Chongsuphajaisiddhi T, Butraporn P, Attanath P, Pasuralertsakul S, Kittikoon P, Banchuin K, Chanthavanich P, Singhasivanon V, Kunstadter P
Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
J Diarrhoeal Dis Res. 1992 Dec;10(4):221-6.
To determine factors related to dehydration from diarrhoea, we conducted a hospital-based, case-control study in children aged 24 months or younger who had acute watery diarrhoea and attended Chonburi Regional Hospital in central Thailand during November 1988 through May 1989. The study compared 48 cases who had moderate or severe dehydration with 48 controls who had no dehydration. Both cases and controls belonged to low socioeconomic families and were living in urban slum areas. They had adequate health care facilities and access to ORS packets. Overall, 56% of the mothers used ORS solution at home. None of the mothers knew how to administer ORS, i.e. the fluid was not given at the onset of diarrhoea to prevent dehydration, and they gave no more than 60 ml over a 24-hour period to their dehydrated children. They also did not use home fluids. Multivariate analysis of data showed two factors significantly associated with dehydration: children's dirty fingernails that indicated inadequate maternal hygiene-related behaviour (Odds Ratio 6.4; 95% Confidence Intervals 1.5-27.6, p < 0.01), and frequency of vomiting in the 24 hours before rehydration (Odds Ratio 1.3; 95% Confidence Intervals 1.1-1.6, p < 0.001). Cases and controls had similar aetiologic agents and nutritional status. Providing proper education to mothers about oral rehydration therapy with special emphasis on the volume of ORS to be given, along with guidance to improve their personal hygiene should be considered important interventions in reducing the risk of dehydration and deaths from diarrhoea in these children.
为了确定与腹泻所致脱水相关的因素,我们于1988年11月至1989年5月期间,在泰国中部春武里地区医院,对24个月及以下患有急性水样腹泻的儿童开展了一项基于医院的病例对照研究。该研究将48例中度或重度脱水患儿与48例无脱水的对照患儿进行了比较。病例组和对照组均来自社会经济地位较低的家庭,居住在城市贫民窟地区。他们有充足的医疗保健设施,并且能够获得口服补液盐(ORS)包。总体而言,56%的母亲在家中使用了ORS溶液。没有一位母亲知道如何服用ORS,即没有在腹泻开始时给予液体以预防脱水,而且她们给脱水孩子在24小时内服用的量不超过60毫升。她们也没有使用家庭自制液体。对数据进行多变量分析显示,有两个因素与脱水显著相关:儿童指甲脏表明母亲在个人卫生方面的行为不当(比值比6.4;95%置信区间1.5 - 27.6,p < 0.01),以及补液前24小时内呕吐频率(比值比1.3;95%置信区间1.1 - 1.6,p < 0.001)。病例组和对照组的病原体及营养状况相似。向母亲们提供关于口服补液疗法的适当教育,特别强调ORS的服用量,并指导她们改善个人卫生,应被视为降低这些儿童脱水风险及腹泻死亡风险的重要干预措施。