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L-抗坏血酸2-O-α-葡萄糖苷的生物利用度和生物活性。

Bioavailability and biological activity of L-ascorbic acid 2-O-alpha-glucoside.

作者信息

Yamamoto I, Muto N

机构信息

Department of Immunochemistry, Okayama University, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:161-4. doi: 10.3177/jnsv.38.special_161.

DOI:10.3177/jnsv.38.special_161
PMID:1297731
Abstract

AA-2G is a new stable derivative of AsA which is efficiently synthesized by regioselective transglucosylation with alpha-glucosidase and CGTase. AA-2G serves as a vitamin C supplement in experimental animals. AA-2G is easily hydrolyzed in vivo by alpha-glucosidase and also synthesized as a metabolite under some specified conditions. AA-2G stimulates collagen synthesis in cultured fibroblasts and enhances antibody production in cultured splenocytes. AA-2G which has no cytotoxicity is a promising AsA derivative for medical and nutritional uses.

摘要

AA - 2G是抗坏血酸（AsA）的一种新型稳定衍生物，它通过α - 葡萄糖苷酶和环糊精葡萄糖基转移酶的区域选择性转葡糖基化反应高效合成。AA - 2G在实验动物中用作维生素C补充剂。AA - 2G在体内易被α - 葡萄糖苷酶水解，并且在某些特定条件下也作为代谢产物合成。AA - 2G可刺激培养的成纤维细胞中的胶原蛋白合成，并增强培养的脾细胞中的抗体产生。无细胞毒性的AA - 2G是一种有前景的用于医学和营养用途的AsA衍生物。

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