Han T, Minowada J, Subramanian S, Sinks L F
Immunology. 1976 Mar;30(3):361-6.
Human allogeneic 'one-way' mixed lymphocyte reactions between thymus cells and thymus cells were entirely absent. Of twenty-one mixed lymphocyte reactions between peripheral blood lymphocytes as responding cells and thymus cells as stimulating cells, only eleven had a weak but significant reaction. In contrast, a highly significant response was observed in each of eighteen mixed lymphocyte reactions between thymus cells as responding cells and peripheral blood lymphocytes as stimulating cells and in each of eleven mixed lymphocyte reactions between peripheral blood lymphocytes and peripheral blood lymphocytes. These findings indicate that the thymus cells (T lymphocytes) possess excellent proliferative capacity, with little or no stimulating capacity, while peripheral blood lymphocytes (T and B lymphocytes), on the other hand, are good responders, as well as good stimulators, in the mixed lymphocyte reaction.
胸腺细胞与胸腺细胞之间完全不存在人类同种异体“单向”混合淋巴细胞反应。在以外周血淋巴细胞作为反应细胞、胸腺细胞作为刺激细胞的21次混合淋巴细胞反应中，只有11次有微弱但显著的反应。相比之下，在以胸腺细胞作为反应细胞、外周血淋巴细胞作为刺激细胞的18次混合淋巴细胞反应中的每一次，以及在以外周血淋巴细胞与外周血淋巴细胞之间的11次混合淋巴细胞反应中的每一次，均观察到高度显著的反应。这些发现表明，胸腺细胞（T淋巴细胞）具有出色的增殖能力，但刺激能力很小或没有，而外周血淋巴细胞（T和B淋巴细胞）在混合淋巴细胞反应中既是良好的反应细胞，也是良好的刺激细胞。
