Whetstone C A, Miller J M, Seal B S, Bello L J, Lawrence W C
National Animal Disease Center, Agricultural Research Service, Ames, Iowa.
Arch Virol. 1992;122(1-2):207-14. doi: 10.1007/BF01321129.
A bovine herpesvirus 1 (BHV 1) mutant variant with a deletion in the thymidine kinase (TK) gene was assessed for its ability to establish latency and be reactivated in cattle. After treatment with dexamethasone, reactivated TK- BHV 1 was isolated from one of four cattle that received virus by intravenous inoculation only, and from four of four cattle that received virus by intranasal, intravaginal, and intravenous inoculation. Results prove that TK- BHV 1 will establish latency and can be reactivated in the natural host.
对一种胸苷激酶（TK）基因缺失的牛疱疹病毒1型（BHV 1）突变变体在牛体内建立潜伏状态并被重新激活的能力进行了评估。在用地塞米松处理后，仅通过静脉接种接受病毒的四头牛中的一头以及通过鼻内、阴道内和静脉接种接受病毒的四头牛中的四头都分离出了重新激活的TK-BHV 1。结果证明，TK-BHV 1能够在天然宿主体内建立潜伏状态并被重新激活。
