Weiss L M, Movahed L A, Butler A E, Swanson S A, Frierson H F, Cooper P H, Colby T V, Mills S E
Department of Pathology, Stanford University, California 94305.
Am J Surg Pathol. 1989 Aug;13(8):625-31. doi: 10.1097/00000478-198908000-00001.
Lymphoepithelioma of the nasopharynx has a strong association with Epstein-Barr virus (EBV). To test the hypothesis that lymphoepithelioma-like carcinomas occurring at other sites are also associated with EBV virus, we used in situ hybridization to analyze 20 cases of lymphoepithelioma and histologically similar lesions and five basaloid squamous cell carcinomas for evidence of EBV genomes. EBV genomes were demonstrated in six of six lymphoepitheliomas of the nasopharynx but in none of five basaloid squamous cell carcinoma. Only one of 14 lymphoepithelioma-like carcinomas was found to contain EBV genomes. The single positive lymphoepithelioma-like carcinoma occurred in the lung of an Asian patient, suggesting that ethnic or geographic influences may be important in determining whether EBV is associated with these nonnasopharyngeal neoplasms. Despite their histologic similarity, most lymphoepithelioma-like carcinomas probably have a different pathogenesis from nasopharyngeal lymphoepithelioma.
鼻咽癌的淋巴上皮瘤与爱泼斯坦-巴尔病毒（EBV）密切相关。为了验证其他部位发生的淋巴上皮瘤样癌也与EBV病毒有关这一假说，我们采用原位杂交技术对20例淋巴上皮瘤及组织学相似病变以及5例基底样鳞状细胞癌进行分析，以寻找EBV基因组的证据。在6例鼻咽部淋巴上皮瘤中均检测到EBV基因组，但5例基底样鳞状细胞癌中均未检测到。14例淋巴上皮瘤样癌中仅1例含有EBV基因组。这例呈阳性的淋巴上皮瘤样癌发生在一名亚洲患者的肺部，提示种族或地理因素在决定EBV是否与这些非鼻咽部肿瘤相关方面可能很重要。尽管它们在组织学上相似，但大多数淋巴上皮瘤样癌的发病机制可能与鼻咽部淋巴上皮瘤不同。
